A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin
- PMID:1962194
- DOI: 10.1126/science.1962194
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin
Abstract
Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. A monoclonal antibody to bovine plakoglobin recognizes the analogous beta catenin in the Madin-Darby canine kidney (MDCK) cell line. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.
Similar articles
- The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM.Peifer M, et al.J Cell Biol. 1992 Aug;118(3):681-91. doi: 10.1083/jcb.118.3.681.J Cell Biol. 1992.PMID:1639851Free PMC article.
- Catenins as mediators of the cytoplasmic functions of cadherins.Gumbiner BM, McCrea PD.Gumbiner BM, et al.J Cell Sci Suppl. 1993;17:155-8. doi: 10.1242/jcs.1993.supplement_17.22.J Cell Sci Suppl. 1993.PMID:8144692Review.
- The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis.DeMarais AA, Moon RT.DeMarais AA, et al.Dev Biol. 1992 Oct;153(2):337-46. doi: 10.1016/0012-1606(92)90118-z.Dev Biol. 1992.PMID:1397690
- Defining E-cadherin-associated protein complexes in epithelial cells: plakoglobin, beta- and gamma-catenin are distinct components.Piepenhagen PA, Nelson WJ.Piepenhagen PA, et al.J Cell Sci. 1993 Mar;104 ( Pt 3):751-62. doi: 10.1242/jcs.104.3.751.J Cell Sci. 1993.PMID:8267793
- Cadherin-catenin complex: protein interactions and their implications for cadherin function.Aberle H, Schwartz H, Kemler R.Aberle H, et al.J Cell Biochem. 1996 Jun 15;61(4):514-23. doi: 10.1002/(SICI)1097-4644(19960616)61:4%3C514::AID-JCB4%3E3.0.CO;2-R.J Cell Biochem. 1996.PMID:8806074Review.
Cited by
- Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.Goentoro L, Kirschner MW.Goentoro L, et al.Mol Cell. 2009 Dec 11;36(5):872-84. doi: 10.1016/j.molcel.2009.11.017.Mol Cell. 2009.PMID:20005849Free PMC article.
- Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac.Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD.Fang X, et al.J Cell Biol. 2004 Apr;165(1):87-98. doi: 10.1083/jcb.200307109. Epub 2004 Apr 5.J Cell Biol. 2004.PMID:15067024Free PMC article.
- No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts.Filimonow K, Saiz N, Suwińska A, Wyszomirski T, Grabarek JB, Ferretti E, Piliszek A, Plusa B, Maleszewski M.Filimonow K, et al.PLoS One. 2019 Feb 8;14(2):e0212109. doi: 10.1371/journal.pone.0212109. eCollection 2019.PLoS One. 2019.PMID:30735538Free PMC article.
- Wnt signaling in periodontitis.Güney Z, Kurgan Ş, Önder C, Tayman MA, Günhan Ö, Kantarci A, Serdar MA, Günhan M.Güney Z, et al.Clin Oral Investig. 2023 Nov;27(11):6801-6812. doi: 10.1007/s00784-023-05294-7. Epub 2023 Oct 10.Clin Oral Investig. 2023.PMID:37814163
- The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica.Peifer M, Wieschaus E.Peifer M, et al.J Mol Evol. 1993 Mar;36(3):224-33. doi: 10.1007/BF00160477.J Mol Evol. 1993.PMID:8483160
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases