Discovery, structure and biological activities of cyclotides
- PMID:19470399
- DOI: 10.1016/j.addr.2009.05.003
Discovery, structure and biological activities of cyclotides
Abstract
Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized peptide backbone and a knotted arrangement of three conserved disulfide bonds. They are present in many plants from the Violaceae, Rubiaceae and Cucurbitaceae families, with individual plants expressing a suite of dozens of cyclotides. So far >140 sequences and 15 three-dimensional structures have been determined but it is estimated that the family probably comprises many thousands of members. Their primary function in plants is thought to be as defense agents, based on their potent insecticidal activity, but they also have a range of other biological activities, including anti-HIV, antimicrobial and cytotoxic activities. Because of their exceptional stability they have attracted interest as templates for protein engineering and drug design applications. This article gives an overview of the discovery of cyclotides, describes their unique structural features and range of bioactivities, and discusses their applications in drug design.
Similar articles
- Discovery and applications of the plant cyclotides.Craik DJ.Craik DJ.Toxicon. 2010 Dec 15;56(7):1092-102. doi: 10.1016/j.toxicon.2010.02.021. Epub 2010 Feb 26.Toxicon. 2010.PMID:20219513Review.
- Chemical synthesis and biosynthesis of the cyclotide family of circular proteins.Gunasekera S, Daly NL, Anderson MA, Craik DJ.Gunasekera S, et al.IUBMB Life. 2006 Sep;58(9):515-24. doi: 10.1080/15216540600889532.IUBMB Life. 2006.PMID:17002979Review.
- The cyclotide family of circular miniproteins: nature's combinatorial peptide template.Craik DJ, Cemazar M, Wang CK, Daly NL.Craik DJ, et al.Biopolymers. 2006;84(3):250-66. doi: 10.1002/bip.20451.Biopolymers. 2006.PMID:16440288Review.
- Isolation, sequencing, and structure-activity relationships of cyclotides.Ireland DC, Clark RJ, Daly NL, Craik DJ.Ireland DC, et al.J Nat Prod. 2010 Sep 24;73(9):1610-22. doi: 10.1021/np1000413.J Nat Prod. 2010.PMID:20718473Review.
- Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.Poth AG, Colgrave ML, Philip R, Kerenga B, Daly NL, Anderson MA, Craik DJ.Poth AG, et al.ACS Chem Biol. 2011 Apr 15;6(4):345-55. doi: 10.1021/cb100388j. Epub 2011 Jan 20.ACS Chem Biol. 2011.PMID:21194241
Cited by
- Identification of Peptides in Flowers ofSambucus nigra with Antimicrobial Activity against Aquaculture Pathogens.Álvarez CA, Barriga A, Albericio F, Romero MS, Guzmán F.Álvarez CA, et al.Molecules. 2018 Apr 27;23(5):1033. doi: 10.3390/molecules23051033.Molecules. 2018.PMID:29702623Free PMC article.
- Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide.Tong Z, Xie X, Ge H, Jiao R, Wang T, Wang X, Zhuang W, Hu G, Tan R.Tong Z, et al.Acta Pharm Sin B. 2024 Feb;14(2):881-892. doi: 10.1016/j.apsb.2023.09.006. Epub 2023 Sep 19.Acta Pharm Sin B. 2024.PMID:38322339Free PMC article.
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.Arnison PG, et al.Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f.Nat Prod Rep. 2013.PMID:23165928Free PMC article.Review.
- Legume cyclotides shed light on the genetic origin of knotted circular proteins.Camarero JA.Camarero JA.Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10025-6. doi: 10.1073/pnas.1107849108. Epub 2011 Jun 8.Proc Natl Acad Sci U S A. 2011.PMID:21653883Free PMC article.No abstract available.
- Antimicrobial Peptides from Plants.Tam JP, Wang S, Wong KH, Tan WL.Tam JP, et al.Pharmaceuticals (Basel). 2015 Nov 16;8(4):711-57. doi: 10.3390/ph8040711.Pharmaceuticals (Basel). 2015.PMID:26580629Free PMC article.Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources