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.2009 Jan;139(1):122-6.
doi: 10.1016/j.virusres.2008.10.001. Epub 2008 Dec 4.

Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate

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Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate

Christopher M Robinson et al. Virus Res.2009 Jan.

Abstract

Human adenovirus type 19 (HAdV-19) is a major etiologic agent of epidemic keratoconjunctivitis (EKC), a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation. Ironically, while the prototype strain of HAdV-19 does not cause eye infections, other isolates of the serotype have caused major outbreaks of EKC. Here we have sequenced a clinical isolate of HAdV-19 (HAdV-19 strain C) from a human patient with EKC. Global pairwise alignment of HAdV-19C to other HAdV species D serotypes identified areas of sequence divergence in the penton base (host cell internalization signal), hexon (principal viral capsid structural protein), E3 (site of immunomodulatory genes), and fiber (host cell-binding ligand) regions. Comparison of HAdV-19 strain C to the recently sequenced HAdV-37, another EKC causing serotype, identified sequence diversity in the penton base and hexon, but sequence conservation in the E3 and fiber regions. Elucidation of the HAdV-19C genome will facilitate future studies into the pathogenesis of EKC, and may shed light on the genetic determinants of corneal tropism.

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Figures

Fig. 1
Fig. 1
Global pairwise sequence comparison of HAdV-19 C with 7 other HAdV species D serotypes using the online sequence alignment program, mVISTA LAGAN. Percent sequence conservation is reflected in the height of each data point along the y axis. The penton, hexon, E3, and fiber regions of HAdV-19 C diverged from those of all other serotypes within species D, except for HAdV-37. The E3 and fiber regions were 100% identical between HAdV-19 and HAdV-37.
Fig. 2
Fig. 2
Bootstrap confirmed neighbor joining tree designed from MEGA 4.0.2 demonstrate phylogenetic relationships between HAdV-19 C (arrow) and all other completely sequenced adenovirus genomes (Saitou and Nei, 1987; Tamura et al., 2007). The nucleotide p-distance model was used, with pairwise deletion options. Bootstrap confidence levels (1000 replicates) are shown as percentages on each branch (Felsenstein, 1985).
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References

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