Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Public Library of Science full text link Public Library of Science Free PMC article
Full text links

Actions

.2008 Feb 29;4(2):e1000010.
doi: 10.1371/journal.pgen.1000010.

Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken

Affiliations

Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken

Jonas Eriksson et al. PLoS Genet..

Abstract

Yellow skin is an abundant phenotype among domestic chickens and is caused by a recessive allele (W*Y) that allows deposition of yellow carotenoids in the skin. Here we show that yellow skin is caused by one or more cis-acting and tissue-specific regulatory mutation(s) that inhibit expression of BCDO2 (beta-carotene dioxygenase 2) in skin. Our data imply that carotenoids are taken up from the circulation in both genotypes but are degraded by BCDO2 in skin from animals carrying the white skin allele (W*W). Surprisingly, our results demonstrate that yellow skin does not originate from the red junglefowl (Gallus gallus), the presumed sole wild ancestor of the domestic chicken, but most likely from the closely related grey junglefowl (Gallus sonneratii). This is the first conclusive evidence for a hybrid origin of the domestic chicken, and it has important implications for our views of the domestication process.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Adapted from ,.
Panel A depicts a map of South Asia onto which the ranges of four species of junglefowl are drawn. Panel B depicts a European domestic chicken with yellow legs. Red, grey, blue, and green regions represent the respective ranges of red, grey, Ceylon, and green junglefowls. Images of these birds are presented in panels C through F respectively, within colored borders that correspond to the colors on the map. (Photo: Figures 1B: Björn Jacobsson; 1C: Erik Bongcam-Rudloff; 1D: John Corder, World Pheasant Association; 1E: Jean Howman, World Pheasant Association; 1F: Kenneth W Fink, World Pheasant Association).
Figure 2
Figure 2
(A) Gene content of theyellow skin interval. The 23.8 kb region showing complete association withyellow skin is indicated by a box. The annotation is based on the chicken genome assembly as presented on the UCSC server (http://genome.ucsc.edu; Build May2006). (B) Differential expression of theBCDO2 transcript in skin but not liver fromyellow skin heterozygotes using genomic DNA (gDNA) as control. The polymorphic position chr24:6,268,434 bp was used to monitor differential expression using pyrosequencing. T and C at this position correspond to thewhite andyellow skin alleles respectively. (C) Summary of the examination of differential expression in skin and liver from six heterozygous (W/Y) birds. Genomic DNA from the three different genotypes were used as controls.
Figure 3
Figure 3. A neighbor-joining tree depicting the relationships between sequences derived from 23.8 kb of theBCDO2 locus.
In total, eleven birds were re-sequenced (the identity number of each bird is given in parenthesis); UCD1 represents the reference genome sequence. Wild and domestic samples possessing white and yellow skin clearly separate into two divergent clades. Node support values were generated from 1000 bootstrap replicates. The relative position of the Grey junglefowl (Delhi) is a result of the fact that this sample was heterozygous for two alleles, one of which most closely matched GryJF_04-7 and another which more closely matched TY_216372. Heterozygous positions were coded using degenerate bases and thus the algorithm used to draw the neighbor-joining tree placed this sample into a relatively basal position. Figure S7 shows the differing nucleotide positions across this region.
See this image and copyright information in PMC

References

    1. Hutt FB. Genetics of the Fowl. New York: McGraw Hill Book Company Inc; 1949.
    1. West B, Zhou B-X. Did chickens go North? New evidence for domestication. J Archaeol Sci. 1988;15:515–533.
    1. Liu YP, Wu GS, Yao YG, Miao YW, Luikart G, et al. Multiple maternal origins of chickens: out of the Asian jungles. Mol Phylogenet Evol. 2006;38:12–19. - PubMed
    1. Darwin C. The variation of animals and plants under domestication. London: John Murray; 1868.
    1. Fumihito A, Miyake T, Takada M, Shingu R, Endo T, et al. Monophyletic origin and unique dispersal patterns of domestic fowls. Proc Natl Acad Sci USA. 1996;93:6792–6795. - PMC - PubMed

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full text links
Public Library of Science full text link Public Library of Science Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp