Drosophila is an inclusive model for human diseases, growth and development
- PMID:18374475
- DOI: 10.1016/j.mce.2008.02.009
Drosophila is an inclusive model for human diseases, growth and development
Abstract
Cytogenetic studies over the last century have led to the complete mapping of the Drosophila polytene chromosomes. The resulting data and the analysis of puffing at specific gene sites, manifestations of enhanced transcriptional activity, have led to the use of the fruit fly as the most well-understood animal model for a plethora of cellular mechanisms and genetic defects. In recent years the fly data base has contributed greatly to the use of Drosophila as a remarkable model for the functional genomics of many human genes. Here I review briefly the diversity of "model genes" studied in this dipteran, ranging from mental acuity, sleep and development, to recent studies from our laboratory, and those of our collaborators, on steroid hormone biosynthesis and neurodegeneration.
Similar articles
- Drosophila: a "model" model system to study neurodegeneration.Celotto AM, Palladino MJ.Celotto AM, et al.Mol Interv. 2005 Oct;5(5):292-303. doi: 10.1124/mi.5.5.9.Mol Interv. 2005.PMID:16249525Review.
- Demented flies? Using Drosophila to model human neurodegenerative diseases.Michno K, van de Hoef D, Wu H, Boulianne GL.Michno K, et al.Clin Genet. 2005 Jun;67(6):468-75. doi: 10.1111/j.1399-0004.2005.00448.x.Clin Genet. 2005.PMID:15857410
- Modeling age-related diseases in Drosophila: can this fly?Michno K, van de Hoef D, Wu H, Boulianne GL.Michno K, et al.Curr Top Dev Biol. 2005;71:199-223. doi: 10.1016/S0070-2153(05)71006-1.Curr Top Dev Biol. 2005.PMID:16344106Review.
- Drosophila in the study of neurodegenerative disease.Marsh JL, Thompson LM.Marsh JL, et al.Neuron. 2006 Oct 5;52(1):169-78. doi: 10.1016/j.neuron.2006.09.025.Neuron. 2006.PMID:17015234Review.
- The drosophila genome and its oncological implications.Rew DA.Rew DA.Eur J Surg Oncol. 2001 Feb;27(1):105-8. doi: 10.1053/ejso.2000.1039.Eur J Surg Oncol. 2001.PMID:11247631
Cited by
- Ecdysteroid hormone action.Spindler KD, Hönl C, Tremmel Ch, Braun S, Ruff H, Spindler-Barth M.Spindler KD, et al.Cell Mol Life Sci. 2009 Dec;66(24):3837-50. doi: 10.1007/s00018-009-0112-5.Cell Mol Life Sci. 2009.PMID:19669094Free PMC article.Review.
- Insectin vitro System for Toxicology Studies - Current and Future Perspectives.Cc S, Arun D, Divya L.Cc S, et al.Front Toxicol. 2021 Jul 19;3:671600. doi: 10.3389/ftox.2021.671600. eCollection 2021.Front Toxicol. 2021.PMID:35295131Free PMC article.Review.
- Release of Applied Mechanical Loading Stimulates Intercellular Calcium Waves in Drosophila Wing Discs.Narciso CE, Contento NM, Storey TJ, Hoelzle DJ, Zartman JJ.Narciso CE, et al.Biophys J. 2017 Jul 25;113(2):491-501. doi: 10.1016/j.bpj.2017.05.051.Biophys J. 2017.PMID:28746859Free PMC article.
- Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.Deng H.Deng H.Fly (Austin). 2014;8(1):7-12. doi: 10.4161/fly.27007. Epub 2013 Nov 1.Fly (Austin). 2014.PMID:24406335Free PMC article.
- Cocoon-Spinning Behavior and 20-Hydroxyecdysone Regulation of Fibroin Genes inPlutella xylostella.Shi Y, Lin GL, Fu XL, Keller M, Smagghe G, Liu TX.Shi Y, et al.Front Physiol. 2020 Dec 15;11:574800. doi: 10.3389/fphys.2020.574800. eCollection 2020.Front Physiol. 2020.PMID:33384607Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Molecular Biology Databases