Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
- PMID:18215222
- DOI: 10.1111/j.1365-2672.2007.03520.x
Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
Abstract
Most studies involving prebiotic oligosaccharides have been carried out using inulin and its fructo-oligosaccharide (FOS) derivatives, together with various forms of galacto-oligosaccharides (GOS). Although many intestinal bacteria are able to grow on these carbohydrates, most investigations have demonstrated that the growth of bifidobacteria, and to a lesser degree lactobacilli, is particularly favoured. Because of their safety, stability, organoleptic properties, resistance to digestion in the upper bowel and fermentability in the colon, as well as their abilities to promote the growth of beneficial bacteria in the gut, these prebiotics are being increasingly incorporated into the Western diet. Inulin-derived oligosaccharides and GOS are mildly laxative, but can result in flatulence and osmotic diarrhoea if taken in large amounts. However, their effects on large bowel habit are relatively minor. Although the literature dealing with the health significance of prebiotics is not as extensive as that concerning probiotics, considerable evidence has accrued showing that consumption of GOS and FOS can have significant health benefits, particularly in relation to their putative anti-cancer properties, influence on mineral absorption, lipid metabolism, and anti-inflammatory and other immune effects such as atopic disease. In many instances, prebiotics seem to be more effective when used as part of a synbiotic combination.
Similar articles
- [Probiotics].Wisker E.Wisker E.Zentralbl Gynakol. 2003 Dec;125(12):475-9. doi: 10.1055/s-2003-44811.Zentralbl Gynakol. 2003.PMID:14755357Review.German.
- Relationship of prebiotics and food to intestinal microflora.Blaut M.Blaut M.Eur J Nutr. 2002 Nov;41 Suppl 1:I11-6. doi: 10.1007/s00394-002-1102-7.Eur J Nutr. 2002.PMID:12420111Review.
- Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects.Bosscher D, Breynaert A, Pieters L, Hermans N.Bosscher D, et al.J Physiol Pharmacol. 2009 Dec;60 Suppl 6:5-11.J Physiol Pharmacol. 2009.PMID:20224145Review.
- Prebiotic effects of inulin and oligofructose.Kolida S, Tuohy K, Gibson GR.Kolida S, et al.Br J Nutr. 2002 May;87 Suppl 2:S193-7. doi: 10.1079/BJNBJN/2002537.Br J Nutr. 2002.PMID:12088518Review.
- Review article: prebiotics in the gastrointestinal tract.Macfarlane S, Macfarlane GT, Cummings JH.Macfarlane S, et al.Aliment Pharmacol Ther. 2006 Sep 1;24(5):701-14. doi: 10.1111/j.1365-2036.2006.03042.x.Aliment Pharmacol Ther. 2006.PMID:16918875Review.
Cited by
- Effects of tea combined with high-protein meal replacement shakes on anthropometric measurements, lipid profiles, cellular biochemistry, neurochemistry, and microbial metabolism: a prospective observational study.Balliett M, Rasmussen O, Burke JR.Balliett M, et al.J Chiropr Med. 2011 Dec;10(4):272-82. doi: 10.1016/j.jcm.2011.06.005.J Chiropr Med. 2011.PMID:22654685Free PMC article.
- Effect of Dietary Fibers on Cecal Microbiota and Intestinal Tumorigenesis in Azoxymethane Treated A/J Min/+ Mice.Moen B, Henjum K, Måge I, Knutsen SH, Rud I, Hetland RB, Paulsen JE.Moen B, et al.PLoS One. 2016 May 19;11(5):e0155402. doi: 10.1371/journal.pone.0155402. eCollection 2016.PLoS One. 2016.PMID:27196124Free PMC article.
- Oligosaccharides Modulate Rotavirus-Associated Dysbiosis and TLR Gene Expression in Neonatal Rats.Azagra-Boronat I, Massot-Cladera M, Knipping K, Van't Land B, Tims S, Stahl B, Knol J, Garssen J, Franch À, Castell M, Pérez-Cano FJ, Rodríguez-Lagunas MJ.Azagra-Boronat I, et al.Cells. 2019 Aug 11;8(8):876. doi: 10.3390/cells8080876.Cells. 2019.PMID:31405262Free PMC article.
- Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus.Andersen JM, Barrangou R, Abou Hachem M, Lahtinen S, Goh YJ, Svensson B, Klaenhammer TR.Andersen JM, et al.Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17785-90. doi: 10.1073/pnas.1114152108. Epub 2011 Oct 17.Proc Natl Acad Sci U S A. 2011.PMID:22006318Free PMC article.
- The role of probiotics and prebiotics in inducing gut immunity.Vieira AT, Teixeira MM, Martins FS.Vieira AT, et al.Front Immunol. 2013 Dec 12;4:445. doi: 10.3389/fimmu.2013.00445.Front Immunol. 2013.PMID:24376446Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources