Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b
- PMID:18177226
- DOI: 10.1086/525259
Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b
Abstract
Background: Acute gastroenteritis is commonly associated with norovirus genogroup II (GII) infection. Norovirus GII has 17 classified genotypes (GII.1-GII.17), but only 1 norovirus genotype (GII.4) is associated with global epidemics of gastroenteritis. In 2006, an increase in global norovirus activity was observed.
Methods: During the period from December 2005 through August 2006, a total of 231 fecal samples were obtained from patients with acute gastroenteritis from Australia and New Zealand. Norovirus RNA was amplified and sequenced to determine norovirus genotype and relatedness to known epidemic norovirus GII.4 variants.
Results: Two GII.4 variants, designated 2006a and 2006b, were identified in 61.8% and 11.3%, respectively, of the 186 cases investigated. Norovirus 2006a and 2006b have also been implicated as the predominant causes of norovirus-associated gastroenteritis across Europe in 2006.
Conclusions: The global increase in norovirus-associated gastroenteritis in 2006 was linked to the emergence of 2 novel GII.4 variants, 2006a and 2006b.
Similar articles
- Sequential evolution of genotype GII.4 norovirus variants causing gastroenteritis outbreaks from 2001 to 2006 in Eastern Spain.Buesa J, Montava R, Abu-Mallouh R, Fos M, Ribes JM, Bartolomé R, Vanaclocha H, Torner N, Domínguez A.Buesa J, et al.J Med Virol. 2008 Jul;80(7):1288-95. doi: 10.1002/jmv.21182.J Med Virol. 2008.PMID:18461627
- Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007.Siebenga JJ, Vennema H, Zheng DP, Vinjé J, Lee BE, Pang XL, Ho EC, Lim W, Choudekar A, Broor S, Halperin T, Rasool NB, Hewitt J, Greening GE, Jin M, Duan ZJ, Lucero Y, O'Ryan M, Hoehne M, Schreier E, Ratcliff RM, White PA, Iritani N, Reuter G, Koopmans M.Siebenga JJ, et al.J Infect Dis. 2009 Sep 1;200(5):802-12. doi: 10.1086/605127.J Infect Dis. 2009.PMID:19627248
- Genetic drift of norovirus genotype GII-4 in seven consecutive epidemic seasons in Hungary.Reuter G, Pankovics P, Szucs G.Reuter G, et al.J Clin Virol. 2008 Jun;42(2):135-40. doi: 10.1016/j.jcv.2008.02.014. Epub 2008 Apr 16.J Clin Virol. 2008.PMID:18420454
- Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants.Hoa Tran TN, Trainor E, Nakagomi T, Cunliffe NA, Nakagomi O.Hoa Tran TN, et al.J Clin Virol. 2013 Mar;56(3):185-93. doi: 10.1016/j.jcv.2012.11.011. Epub 2012 Dec 5.J Clin Virol. 2013.PMID:23218993Review.
- [Norovirus epidemic strain GII. 4 evolution--a review].Wu Q, Xue L, Zhang J.Wu Q, et al.Wei Sheng Wu Xue Bao. 2012 Dec 4;52(12):1431-8.Wei Sheng Wu Xue Bao. 2012.PMID:23457792Review.Chinese.
Cited by
- Updates on the genetic variations of norovirus in sporadic gastroenteritis in Chungnam Korea, 2009-2010.Park K, Yeo S, Jeong H, Baek K, Kim D, Shin M, Song J, Lee S, Choi Y, Park J, Cho S, Cheon D.Park K, et al.Virol J. 2012 Jan 24;9:29. doi: 10.1186/1743-422X-9-29.Virol J. 2012.PMID:22273062Free PMC article.
- Molecular epidemiology of norovirus in Edinburgh healthcare facilities, Scotland 2007-2011.McAllister G, Holmes A, Garcia L, Cameron F, Cloy K, Danial J, Cepeda JA, Simmonds P, Templeton KE.McAllister G, et al.Epidemiol Infect. 2012 Dec;140(12):2273-81. doi: 10.1017/S0950268812000052. Epub 2012 Feb 6.Epidemiol Infect. 2012.PMID:22309708Free PMC article.
- Nonnucleoside inhibitors of norovirus RNA polymerase: scaffolds for rational drug design.Eltahla AA, Lim KL, Eden JS, Kelly AG, Mackenzie JM, White PA.Eltahla AA, et al.Antimicrob Agents Chemother. 2014 Jun;58(6):3115-23. doi: 10.1128/AAC.02799-13. Epub 2014 Mar 17.Antimicrob Agents Chemother. 2014.PMID:24637690Free PMC article.
- Full sequence analysis and characterization of the South Korean Norovirus GII-4 variant CUK-3.Park JW, Lee SG, Lee YM, Jheong WH, Ryu S, Paik SY.Park JW, et al.Virol J. 2011 Apr 14;8:167. doi: 10.1186/1743-422X-8-167.Virol J. 2011.PMID:21489302Free PMC article.
- Influence of novel norovirus GII.4 variants on gastroenteritis outbreak dynamics in Alberta and the Northern Territories, Canada between 2000 and 2008.Pang XL, Preiksaitis JK, Wong S, Li V, Lee BE.Pang XL, et al.PLoS One. 2010 Jul 16;5(7):e11599. doi: 10.1371/journal.pone.0011599.PLoS One. 2010.PMID:20661286Free PMC article.
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Medical