Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

American Society for Clinical Investigation full text link American Society for Clinical Investigation Free PMC article
Full text links

Actions

Review
.2008 Jan;118(1):6-14.
doi: 10.1172/JCI32483.

Antipsychotics in the treatment of autism

Affiliations
Review

Antipsychotics in the treatment of autism

David J Posey et al. J Clin Invest.2008 Jan.

Abstract

Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Simplified schematic of a DA synapse showing synthesis of DA, a postsynaptic D2 receptor, and intracellular mechanisms.
Most conventional and atypical antipsychotics block DA D2 receptors. The D2 receptor is coupled by an inhibitory G protein (Gi) to adenylyl cyclase (AC), which converts ATP to cAMP, a secondary messenger.
Figure 2
Figure 2. Simplified schematic of a serotonin (5-HT) synapse showing synthesis of 5-HT, a postsynaptic 5-HT2 receptor, and intracellular mechanisms.
In contrast to conventional antipsychotics, most atypical antipsychotics block 5-HT2 receptors. The 5-HT2 receptor is coupled by a G protein (Gq) to phospholipase C (PLC). Phospholipase C hydrolyzes membrane-bound phosphatidyl inositol (PIP2), generating 2 secondary messengers, inositol triphosphate (IP3) and diacylglycerol (DAG).
See this image and copyright information in PMC

References

    1. Muhle R., Trentacoste S.V., Rapin I. The genetics of autism. Pediatrics. 2004;113:e472–e486. - PubMed
    1. McDougle C.J., Erickson C.A., Stigler K.A., Posey D.J. Neurochemistry in the pathophysiology of autism. J. Clin. Psychiatry. 2005;66(Suppl. 10):9–18. - PubMed
    1. DiMartino A., Castellanos F.X. Functional neuroimaging of social cognition in pervasive developmental disorders: a brief review. Ann. N. Y. Acad. Sci. . 2003;1008:256–260. - PubMed
    1. Allen G., Müller R., Courchesne E. Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task. Biol. Psychiatry. . 2004;56:269–278. - PubMed
    1. Schultz R.T., et al. Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch. Gen. Psychiatry. 2000;57:331–340. - PubMed

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full text links
American Society for Clinical Investigation full text link American Society for Clinical Investigation Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp