Importance of retronasal and orthonasal olfaction for odor aversion memory in rats
- PMID:18085892
- DOI: 10.1037/0735-7044.121.6.1383
Importance of retronasal and orthonasal olfaction for odor aversion memory in rats
Abstract
The role of odors in food memory formation, especially for aversions, has long been considered secondary to taste. However, the importance of odor ingestion in conditioned odor aversion (COA) has recently challenged this assumption (B. M. Slotnick, F. Westbrook, & F. M. C. Darling, 1997). The aim of the present study was to evaluate the respective role of orthonasal and retronasal olfactory experience in COA acquisition, long-term retention, extinction, and spontaneous recovery. To this end, the odor was presented either close to the drinking spout (orthonasal stimulation) or close to and mixed with the drinking water (eliciting both orthonasal and retronasal stimulation). The authors brought evidence that odor ingestion was crucial for COA acquisition, especially when odor presentation and gastric malaise were separated by long delays. On the contrary, once formed, a distal (orthonasal) odor recognition was sufficient for COA to be retrieved. COA was odor specific and long lasting (more than 50 days). Moreover, results brought evidence for a spontaneous recovery of odor aversion tested 57 days after its extinction.
Similar articles
- The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: a multisite electrophysiological study in rats.Chapuis J, Garcia S, Messaoudi B, Thevenet M, Ferreira G, Gervais R, Ravel N.Chapuis J, et al.J Neurosci. 2009 Aug 19;29(33):10287-98. doi: 10.1523/JNEUROSCI.0505-09.2009.J Neurosci. 2009.PMID:19692603Free PMC article.
- Effects of brain lesions on taste-potentiated odor aversion in rats.Inui T, Shimura T, Yamamoto T.Inui T, et al.Behav Neurosci. 2006 Jun;120(3):590-9. doi: 10.1037/0735-7044.120.3.590.Behav Neurosci. 2006.PMID:16768611
- Odor of taste stimuli in conditioned "taste" aversion learning.Capaldi ED, Hunter MJ, Privitera GJ.Capaldi ED, et al.Behav Neurosci. 2004 Dec;118(6):1400-8. doi: 10.1037/0735-7044.118.6.1400.Behav Neurosci. 2004.PMID:15598148
- Taste and odor recognition memory: the emotional flavor of life.Miranda MI.Miranda MI.Rev Neurosci. 2012;23(5-6):481-99. doi: 10.1515/revneuro-2012-0064.Rev Neurosci. 2012.PMID:23072843Review.
- Factors affecting the ortho- and retronasal perception of flavors: A review.Goldberg EM, Wang K, Goldberg J, Aliani M.Goldberg EM, et al.Crit Rev Food Sci Nutr. 2018 Apr 13;58(6):913-923. doi: 10.1080/10408398.2016.1231167. Epub 2017 Jul 5.Crit Rev Food Sci Nutr. 2018.PMID:27646486Review.
Cited by
- Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of Extinction of Recent and Remote Aversion Memory.Awad W, Ferreira G, Maroun M.Awad W, et al.Neuropsychopharmacology. 2015 Oct;40(11):2566-75. doi: 10.1038/npp.2015.103. Epub 2015 Apr 15.Neuropsychopharmacology. 2015.PMID:25872918Free PMC article.
- Differential Recruitment of the Infralimbic Cortex in Recent and Remote Retrieval and Extinction of Aversive Memory in Post-Weanling Rats.Awad W, Kritman M, Ferreira G, Maroun M.Awad W, et al.Int J Neuropsychopharmacol. 2022 Jun 21;25(6):489-497. doi: 10.1093/ijnp/pyac012.Int J Neuropsychopharmacol. 2022.PMID:35134947Free PMC article.
- Retronasal Odor Perception Requires Taste Cortex, but Orthonasal Does Not.Blankenship ML, Grigorova M, Katz DB, Maier JX.Blankenship ML, et al.Curr Biol. 2019 Jan 7;29(1):62-69.e3. doi: 10.1016/j.cub.2018.11.011. Epub 2018 Dec 20.Curr Biol. 2019.PMID:30581018Free PMC article.
- The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: a multisite electrophysiological study in rats.Chapuis J, Garcia S, Messaoudi B, Thevenet M, Ferreira G, Gervais R, Ravel N.Chapuis J, et al.J Neurosci. 2009 Aug 19;29(33):10287-98. doi: 10.1523/JNEUROSCI.0505-09.2009.J Neurosci. 2009.PMID:19692603Free PMC article.
- Transfer of Odor Perception From the Retronasal to the Orthonasal Pathway.He R, Dukes TC, Kay LM.He R, et al.Chem Senses. 2021 Jan 1;46:bjaa074. doi: 10.1093/chemse/bjaa074.Chem Senses. 2021.PMID:33196792Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical