Meta-Analysis
doi: 10.1111/j.1468-2982.2007.01400.x. Epub 2007 Aug 21.Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis
Affiliations
- PMID:17714520
- DOI: 10.1111/j.1468-2982.2007.01400.x
Item in Clipboard
Meta-Analysis
Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis
E Rubino et al. Cephalalgia.2009 Aug.
Display options
Format
Display options
Format
Abstract
There are conflicting data concerning the association between migraine and C677T polymorphism of the MTHFR gene. The C677T polymorphism reduces enzymatic capability by 50% and causes hyperhomocysteinaemia. We performed a meta-analysis of all published studies investigating the association between the MTHFR gene and migraine. Pooled odds ratios (OR) were estimated using random (RE) and fixed effects (FE) models. Among the overall 2961 migraineurs there was no significant difference compared with controls. Only in migraine with aura was the TT genotype associated with a higher risk of disease compared with the CC genotype [FE OR 1.30, 95% confidence interval (CI) 1.06, 1.58; RE OR 1.66, 95% CI 1.06, 2.59]. In the same subgroup a significant difference was observed in the comparison between TT and CT + CC genotypes (FE OR 1.32, 95% CI 1.10, 1.59; RE OR 1.63, 95% CI 1.10, 2.43). This study provides evidence for an association of the MTHFR gene only in migraine with aura.
Comment in
- Comment on Rubino et al., 'Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis'.Scher AI.Scher AI.Cephalalgia. 2009 Aug;29(8):807-8. doi: 10.1111/j.1468-2982.2009.01848.x.Cephalalgia. 2009.PMID:19604253No abstract available.
Similar articles
- Comment on Rubino et al., 'Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis'.Scher AI.Scher AI.Cephalalgia. 2009 Aug;29(8):807-8. doi: 10.1111/j.1468-2982.2009.01848.x.Cephalalgia. 2009.PMID:19604253No abstract available.
- Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis.Ren A, Wang J.Ren A, et al.Fertil Steril. 2006 Dec;86(6):1716-22. doi: 10.1016/j.fertnstert.2006.05.052. Epub 2006 Oct 30.Fertil Steril. 2006.PMID:17074326
- C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies.Zintzaras E.Zintzaras E.Psychiatr Genet. 2006 Jun;16(3):105-15. doi: 10.1097/01.ypg.0000199444.77291.e2.Psychiatr Genet. 2006.PMID:16691128
- 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis.Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF.Pereira TV, et al.Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1956-63. doi: 10.1158/1055-9965.EPI-06-0334.Cancer Epidemiol Biomarkers Prev. 2006.PMID:17035405Review.
- Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?Peerbooms OL, van Os J, Drukker M, Kenis G, Hoogveld L; MTHFR in Psychiatry Group; de Hert M, Delespaul P, van Winkel R, Rutten BP.Peerbooms OL, et al.Brain Behav Immun. 2011 Nov;25(8):1530-43. doi: 10.1016/j.bbi.2010.12.006. Epub 2010 Dec 24.Brain Behav Immun. 2011.PMID:21185933Review.
Cited by
- Analysis of the DNA methylation pattern of the promoter region of calcitonin gene-related peptide 1 gene in patients with episodic migraine: An exploratory case-control study.Rubino E, Boschi S, Giorgio E, Pozzi E, Marcinnò A, Gallo E, Roveta F, Grassini A, Brusco A, Rainero I.Rubino E, et al.Neurobiol Pain. 2022 Apr 2;11:100089. doi: 10.1016/j.ynpai.2022.100089. eCollection 2022 Jan-Jul.Neurobiol Pain. 2022.PMID:35445161Free PMC article.
- Association between serum levels of homocysteine with characteristics of migraine attacks in migraine with aura.Sadeghi O, Maghsoudi Z, Askari G, Khorvash F, Feizi A.Sadeghi O, et al.J Res Med Sci. 2014 Nov;19(11):1041-5.J Res Med Sci. 2014.PMID:25657748Free PMC article.
- Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to epilepsy.Rai V, Kumar P.Rai V, et al.Neurol Sci. 2018 Dec;39(12):2033-2041. doi: 10.1007/s10072-018-3583-z. Epub 2018 Sep 28.Neurol Sci. 2018.PMID:30267335
- Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.Jung A, Huge A, Kuhlenbäumer G, Kempt S, Seehafer T, Evers S, Berger K, Marziniak M.Jung A, et al.J Neural Transm (Vienna). 2010 Nov;117(11):1253-60. doi: 10.1007/s00702-010-0468-6. Epub 2010 Aug 26.J Neural Transm (Vienna). 2010.PMID:20740293
- Newest aspects on the association between migraine and cardiovascular disease: the role of modifying factors.Kurth T, Schürks M.Kurth T, et al.Curr Pain Headache Rep. 2009 Jun;13(3):231-6. doi: 10.1007/s11916-009-0039-4.Curr Pain Headache Rep. 2009.PMID:19457285Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous