Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
- PMID:17678505
- DOI: 10.1111/j.1369-1600.2007.00070.x
Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Abstract
Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.
Similar articles
- The utility of the zebrafish model in conditioned place preference to assess the rewarding effects of drugs.Collier AD, Echevarria DJ.Collier AD, et al.Behav Pharmacol. 2013 Sep;24(5-6):375-83. doi: 10.1097/FBP.0b013e328363d14a.Behav Pharmacol. 2013.PMID:23811781Review.
- Social reward-conditioned place preference: a model revealing an interaction between cocaine and social context rewards in rats.Thiel KJ, Okun AC, Neisewander JL.Thiel KJ, et al.Drug Alcohol Depend. 2008 Aug 1;96(3):202-12. doi: 10.1016/j.drugalcdep.2008.02.013. Epub 2008 Apr 21.Drug Alcohol Depend. 2008.PMID:18430522Free PMC article.
- Critical evaluation of the use of extinction paradigms for the assessment of opioid-induced conditioned place preference in rats.Rutten K, van der Kam EL, De Vry J, Tzschentke TM.Rutten K, et al.Pharmacology. 2011;87(5-6):286-96. doi: 10.1159/000327680. Epub 2011 May 17.Pharmacology. 2011.PMID:21577043
- Adolescent male Wistar rats are more responsive than adult rats to the conditioned rewarding effects of intravenously administered nicotine in the place conditioning procedure.Shram MJ, Lê AD.Shram MJ, et al.Behav Brain Res. 2010 Jan 20;206(2):240-4. doi: 10.1016/j.bbr.2009.09.018. Epub 2009 Sep 16.Behav Brain Res. 2010.PMID:19765617
- [Evaluation of the rewarding effects of drugs by conditioned place preference (CPP) paradigm: properties of volatile organic solvents and uncontrolled newly-abused drugs].Funada M, Akitake Y, Aoo N.Funada M, et al.Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008 Oct;43(5):691-6.Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008.PMID:19068775Review.Japanese.
Cited by
- The heritability of oxycodone reward and concomitant phenotypes in a LG/J × SM/J mouse advanced intercross line.Bryant CD, Guido MA, Kole LA, Cheng R.Bryant CD, et al.Addict Biol. 2014 Jul;19(4):552-61. doi: 10.1111/adb.12016. Epub 2012 Dec 12.Addict Biol. 2014.PMID:23231598Free PMC article.
- Chemosensory cue conditioning with stimulants in a Caenorhabditis elegans animal model of addiction.Musselman HN, Neal-Beliveau B, Nass R, Engleman EA.Musselman HN, et al.Behav Neurosci. 2012 Jun;126(3):445-56. doi: 10.1037/a0028303.Behav Neurosci. 2012.PMID:22642886Free PMC article.
- Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition.Peleg-Raibstein D, Sarker G, Litwan K, Krämer SD, Ametamey SM, Schibli R, Wolfrum C.Peleg-Raibstein D, et al.Transl Psychiatry. 2016 Oct 4;6(10):e911. doi: 10.1038/tp.2016.176.Transl Psychiatry. 2016.PMID:27701408Free PMC article.
- The Two Faces of Social Interaction Reward in Animal Models of Drug Dependence.El Rawas R, Saria A.El Rawas R, et al.Neurochem Res. 2016 Mar;41(3):492-9. doi: 10.1007/s11064-015-1637-7. Epub 2015 Jun 19.Neurochem Res. 2016.PMID:26088685Free PMC article.Review.
- Tramadol and Tapentadol Induce Conditioned Place Preference with a Differential Impact on Rewarding Memory and Incubation of Craving.Barbosa J, Leal S, Pereira FC, Dinis-Oliveira RJ, Faria J.Barbosa J, et al.Pharmaceuticals (Basel). 2023 Jan 7;16(1):86. doi: 10.3390/ph16010086.Pharmaceuticals (Basel). 2023.PMID:36678582Free PMC article.
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical