Objective: To observe the effects of resistant starch (RS) on insulin resistance (IR) in type 2 diabetes mellitus patients.

Methods: All 40 patients with type 2 diabetes mellitus were randomly divided into two groups: Group A and Group B. Cross-design of two stages (I, II) was used during observation. Group A received RS 30 g/d as an intervention group for ahead of 4 weeks ( I stage) , while group B as a control group. Group B was given RS in late 4 weeks (II stage), while Group A as served control group. Blood was taken the first day and on the latest day in each stage. Fasting blood glucose (FBG), post blood glucose (PBG), fructosamine (FMN), total cholesterol (TC), triglyceridemic (TG), insulin sensitive index (ISI), and body mass index (BMI) were measured, respectively.

Results: As Compared with the control group, ISI was higher and FBG, PBG, TC, TG, FMN and BMI were significantly lower in intervention group (P < 0.05).

Conclusion: RS should be effective in improving IR of type 2 diabetes mellitus patients.