Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Silverchair Information Systems full text link Silverchair Information Systems
Full text links

Actions

Share

Review
.2007:29:49-61.
doi: 10.1093/epirev/mxm004. Epub 2007 Jun 12.

Genetic epidemiology of obesity

Affiliations
Review

Genetic epidemiology of obesity

Wenjie Yang et al. Epidemiol Rev.2007.

Abstract

Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, stroke, some types of cancer, and premature death worldwide. Obesity is highly heritable and arises from the interactions of multiple genes, environmental factors, and behavior. In this paper, the authors reviewed recent developments in genetic epidemiologic research, focusing particularly on several promising genomic regions and obesity-related genes. Gene-gene and gene-environment interactions of obesity were also discussed. Published studies were accessed through the MEDLINE database. The authors also searched the Obesity Gene Map Database (http://obesitygene.pbrc.edu/) and conducted a manual search using references cited in relevant papers. Heritabilities for obesity-related phenotypes varied from 6% to 85% among various populations. As of October 2005, 253 quantitative trait loci for obesity-related phenotypes have been localized in 61 genome-wide linkage scans, and genetic variants in 127 biologic candidate genes have been reported to be associated with obesity-related phenotypes from 426 positive findings. Gene-gene interactions were also observed in several genes, and some genes were found to influence the effect of dietary intake and physical activity on obesity-related phenotypes. Integration of genetic epidemiology with functional genomics and proteomics studies will be required to fully understand the role of genetic variants in the etiology and prevention of obesity.

PubMed Disclaimer

Similar articles

  • The human obesity gene map: the 2004 update.
    Pérusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Snyder EE, Bouchard C.Pérusse L, et al.Obes Res. 2005 Mar;13(3):381-490. doi: 10.1038/oby.2005.50.Obes Res. 2005.PMID:15833932
  • The human obesity gene map: the 2003 update.
    Snyder EE, Walts B, Pérusse L, Chagnon YC, Weisnagel SJ, Rankinen T, Bouchard C.Snyder EE, et al.Obes Res. 2004 Mar;12(3):369-439. doi: 10.1038/oby.2004.47.Obes Res. 2004.PMID:15044658Review.
  • The human obesity gene map: the 2002 update.
    Chagnon YC, Rankinen T, Snyder EE, Weisnagel SJ, Pérusse L, Bouchard C.Chagnon YC, et al.Obes Res. 2003 Mar;11(3):313-67. doi: 10.1038/oby.2003.47.Obes Res. 2003.PMID:12634430Review.
  • The human obesity gene map: the 2005 update.
    Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Pérusse L, Bouchard C.Rankinen T, et al.Obesity (Silver Spring). 2006 Apr;14(4):529-644. doi: 10.1038/oby.2006.71.Obesity (Silver Spring). 2006.PMID:16741264Review.
  • Health-related disparities: influence of environmental factors.
    Olden K, White SL.Olden K, et al.Med Clin North Am. 2005 Jul;89(4):721-38. doi: 10.1016/j.mcna.2005.02.001.Med Clin North Am. 2005.PMID:15925646Review.
See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Related information

LinkOut - more resources

Full text links
Silverchair Information Systems full text link Silverchair Information Systems
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp