Comment
doi: 10.1016/j.immuni.2007.05.003.T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
Affiliations
- PMID:17521582
- DOI: 10.1016/j.immuni.2007.05.003
Item in Clipboard
Comment
T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
Mandy J McGeachy et al. Immunity.2007 May.
Free article Display options
Format
Display options
Format
Abstract
The source of TGF-beta, which regulates inflammation in various disease settings, is unclear. In this issue of Immunity, Li et al. (2007) find that not only does T cell-produced TGF-beta regulate Th1-cell-mediated inflammation, but it is also required for the generation of Th17 cells in vivo.
Comment on
- T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.Li MO, Wan YY, Flavell RA.Li MO, et al.Immunity. 2007 May;26(5):579-91. doi: 10.1016/j.immuni.2007.03.014. Epub 2007 May 3.Immunity. 2007.PMID:17481928
Similar articles
- T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.Li MO, Wan YY, Flavell RA.Li MO, et al.Immunity. 2007 May;26(5):579-91. doi: 10.1016/j.immuni.2007.03.014. Epub 2007 May 3.Immunity. 2007.PMID:17481928
- TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23.Morishima N, Mizoguchi I, Takeda K, Mizuguchi J, Yoshimoto T.Morishima N, et al.Biochem Biophys Res Commun. 2009 Aug 14;386(1):105-10. doi: 10.1016/j.bbrc.2009.05.140. Epub 2009 Jun 6.Biochem Biophys Res Commun. 2009.PMID:19501566
- TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells.Santarlasci V, Maggi L, Capone M, Frosali F, Querci V, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F.Santarlasci V, et al.Eur J Immunol. 2009 Jan;39(1):207-15. doi: 10.1002/eji.200838748.Eur J Immunol. 2009.PMID:19130583
- Th17 cell differentiation: the long and winding road.McGeachy MJ, Cua DJ.McGeachy MJ, et al.Immunity. 2008 Apr;28(4):445-53. doi: 10.1016/j.immuni.2008.03.001.Immunity. 2008.PMID:18400187Review.
- Developmental plasticity of Th17 and Treg cells.Lee YK, Mukasa R, Hatton RD, Weaver CT.Lee YK, et al.Curr Opin Immunol. 2009 Jun;21(3):274-80. doi: 10.1016/j.coi.2009.05.021. Epub 2009 Jun 11.Curr Opin Immunol. 2009.PMID:19524429Review.
Cited by
- Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells.Pandiyan P, Zhu J.Pandiyan P, et al.Cytokine. 2015 Nov;76(1):13-24. doi: 10.1016/j.cyto.2015.07.005. Epub 2015 Jul 10.Cytokine. 2015.PMID:26165923Free PMC article.Review.
- NP30 stimulates Th17 differentiation through DC in Schistosomiasis Japonicum.Xu L, Xue B, Zhou L, Qiu Z, Zhang X, Xu N, Tang Q, Zhu J, Guan X, Feng Z.Xu L, et al.Parasite Immunol. 2018 May;40(5):e12528. doi: 10.1111/pim.12528.Parasite Immunol. 2018.PMID:29577333Free PMC article.
- Structural and immunohistochemical analysis of the cellular compositions of the liver of molly fish (Poecilia sphenops), focusing on its immune role.Hussein MM, Sayed RKA, Mokhtar DM.Hussein MM, et al.Zoological Lett. 2023 Jan 5;9(1):1. doi: 10.1186/s40851-022-00200-7.Zoological Lett. 2023.PMID:36604695Free PMC article.
- The role of cytokines in Guillain-Barré syndrome.Lu MO, Zhu J.Lu MO, et al.J Neurol. 2011 Apr;258(4):533-48. doi: 10.1007/s00415-010-5836-5. Epub 2010 Nov 23.J Neurol. 2011.PMID:21104265Review.
- IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases.Jung MK, Kwak JE, Shin EC.Jung MK, et al.Immune Netw. 2017 Oct;17(5):276-286. doi: 10.4110/in.2017.17.5.276. Epub 2017 Oct 16.Immune Netw. 2017.PMID:29093649Free PMC article.Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources