T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
- PMID:17521582
- DOI: 10.1016/j.immuni.2007.05.003
T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
Abstract
The source of TGF-beta, which regulates inflammation in various disease settings, is unclear. In this issue of Immunity, Li et al. (2007) find that not only does T cell-produced TGF-beta regulate Th1-cell-mediated inflammation, but it is also required for the generation of Th17 cells in vivo.
Comment on
- T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.Li MO, Wan YY, Flavell RA.Li MO, et al.Immunity. 2007 May;26(5):579-91. doi: 10.1016/j.immuni.2007.03.014. Epub 2007 May 3.Immunity. 2007.PMID:17481928
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