CRISPR provides acquired resistance against viruses in prokaryotes
- PMID:17379808
- DOI: 10.1126/science.1138140
CRISPR provides acquired resistance against viruses in prokaryotes
Abstract
Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophages. We found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus, CRISPR, together with associated cas genes, provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity.
Comment in
- Microbiology. New bacterial defense against phage invaders identified.Marx J.Marx J.Science. 2007 Mar 23;315(5819):1650-1. doi: 10.1126/science.315.5819.1650a.Science. 2007.PMID:17379781No abstract available.
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