Review
doi: 10.1016/j.jdermsci.2006.11.002. Epub 2006 Dec 13.Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis
Affiliations
- PMID:17169531
- DOI: 10.1016/j.jdermsci.2006.11.002
Item in Clipboard
Review
Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis
Hideo Asada. J Dermatol Sci.2007 Mar.
Display options
Format
Display options
Format
Abstract
Hypersensitivity to mosquito bites (HMB) is characterized by intense local skin reactions and systemic symptoms, such as high fever, lymphadenopathy and hepatosplenomegaly. Half of the patients reported died of hemophagocytic syndrome or lymphocyte proliferative disorders. Clinical and laboratory studies have revealed that HMB occurs in association with natural killer (NK) cell lymphocytosis related to chronic Epstein-Barr virus (EBV) infection. Recent studies have clarified the unique pathogenic mechanism of this mysterious disease, and demonstrated the close relationship between HMB and EBV-carrying NK cell lymphocytosis; i.e., CD4(+) T cells from the patients markedly responded to mosquito salivary gland extracts, and the CD4(+) T cells stimulated by mosquito bites may play a key role in the development of HMB and NK cell oncogenesis via the induction of EBV reactivation and EBV-oncogene expression, respectively.
Similar articles
- CD4+ T-lymphocyte-induced Epstein-Barr virus reactivation in a patient with severe hypersensitivity to mosquito bites and Epstein-Barr virus-infected NK cell lymphocytosis.Asada H, Miyagawa S, Sumikawa Y, Yamaguchi Y, Itami S, Suguri S, Harada M, Tokura Y, Ishihara S, Ohshima S, Yoshikawa K.Asada H, et al.Arch Dermatol. 2003 Dec;139(12):1601-7. doi: 10.1001/archderm.139.12.1601.Arch Dermatol. 2003.PMID:14676078
- Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis: the possible implication of Epstein-Barr virus reactivation.Satoh M, Oyama N, Akiba H, Ohtsuka M, Iwatsuki K, Kaneko F.Satoh M, et al.Eur J Dermatol. 2002 Jul-Aug;12(4):381-4.Eur J Dermatol. 2002.PMID:12095889
- Mosquito salivary gland extracts induce EBV-infected NK cell oncogenesis via CD4 T cells in patients with hypersensitivity to mosquito bites.Asada H, Saito-Katsuragi M, Niizeki H, Yoshioka A, Suguri S, Isonokami M, Aoki T, Ishihara S, Tokura Y, Iwatsuki K, Miyagawa S.Asada H, et al.J Invest Dermatol. 2005 Nov;125(5):956-61. doi: 10.1111/j.0022-202X.2005.23915.x.J Invest Dermatol. 2005.PMID:16297196
- Hypersensitivity to mosquito bites is not an allergic disease, but an Epstein-Barr virus-associated lymphoproliferative disease.Ishihara S, Yabuta R, Tokura Y, Ohshima K, Tagawa S.Ishihara S, et al.Int J Hematol. 2000 Aug;72(2):223-8.Int J Hematol. 2000.PMID:11039673Review.
- Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma.Tokura Y, Ishihara S, Tagawa S, Seo N, Ohshima K, Takigawa M.Tokura Y, et al.J Am Acad Dermatol. 2001 Oct;45(4):569-78. doi: 10.1067/mjd.2001.114751.J Am Acad Dermatol. 2001.PMID:11568749Review.
Cited by
- A case of hypersensitivity to mosquito bites without peripheral natural killer cell lymphocytosis in a 6-year-old Korean boy.Seon HS, Roh JH, Lee SH, Kang EK.Seon HS, et al.J Korean Med Sci. 2013 Jan;28(1):164-6. doi: 10.3346/jkms.2013.28.1.164. Epub 2013 Jan 8.J Korean Med Sci. 2013.PMID:23341729Free PMC article.
- Primary EBV infection and hypersensitivity to mosquito bites: a case report.Kyriakidis I, Vasileiou E, Karastrati S, Tragiannidis A, Gompakis N, Hatzistilianou M.Kyriakidis I, et al.Virol Sin. 2016 Dec;31(6):517-520. doi: 10.1007/s12250-016-3868-4.Virol Sin. 2016.PMID:27900557Free PMC article.
- Epstein-Barr virus-related lymphoproliferative disorders.Wagner-Johnston ND, Ambinder RF.Wagner-Johnston ND, et al.Curr Hematol Malig Rep. 2007 Oct;2(4):249-54. doi: 10.1007/s11899-007-0034-y.Curr Hematol Malig Rep. 2007.PMID:20425377Review.
- Insect hypersensitivity beyond bee and wasp venom allergy.Hemmer W, Wantke F.Hemmer W, et al.Allergol Select. 2020 Nov 30;4:97-104. doi: 10.5414/ALX02123E. eCollection 2020.Allergol Select. 2020.PMID:33275648Free PMC article.Review.
- The First Korean Case of Epstein-Barr Virus-positive Natural Killer/T-cell Lymphoma That Progressed From Severe Mosquito Bite Allergy, With Coexistence of Hemophagocytic Lymphohistiocytosis.Lee S, Park CJ, Cho YU, Jang S, Huh J, Kim H.Lee S, et al.Ann Lab Med. 2020 Jan;40(1):80-83. doi: 10.3343/alm.2020.40.1.80.Ann Lab Med. 2020.PMID:31432645Free PMC article.No abstract available.
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Medical
Research Materials