Review
doi: 10.5688/aj700598.Ergot and its alkaloids
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- PMID:17149427
- PMCID: PMC1637017
- DOI: 10.5688/aj700598
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Review
Ergot and its alkaloids
Paul L Schiff. Am J Pharm Educ..
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Abstract
This manuscript reviews the history and pharmacognosy of ergot, and describes the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives. A brief discussion of the hallucinogenic properties of lysergic acid diethylamide is also featured. An abbreviated form of the material found in this paper is presented in a 4-hour didactic format to third-professional year PharmD students as part of their study of vascular migraine headaches, Parkinson's disease, and naturally occurring hallucinogens/hallucinogen derivatives in the modular course offering Neurology/Psychiatry.
Figures
Chemical structures of ergot alkaloids and related important compounds.
Chemical structures of ergot alkaloids and related important compounds.
References
- Swan GA. An Introduction to the Alkaloids. New York, NY: John Wiley & Sons, Inc; 1967. pp. 209–215.
- Cordell GA. Introduction to Alkaloids. New York, NY: John Wiley & Sons; 1981. pp. 622–655.
- Trease GE, Evans WC. Pharmacognosy. 12th ed. London, England: Bailliere Tindall; 1983. pp. 599–605.
- Řeháček Z, Sajdl P. Ergot Alkaloids. New York, NY: Elsevier Science Publishing Company; 1990. pp. 28–86.
- Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants, Paris, France: Technique & Documentation, Lavoisier; 1995. pp. 797–814.
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