Review
doi: 10.1210/er.2006-0040. Epub 2006 Nov 22.Genetics of obesity in humans
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- PMID:17122358
- DOI: 10.1210/er.2006-0040
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Review
Genetics of obesity in humans
Sadaf Farooqi et al. Endocr Rev.2006 Dec.
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Abstract
Considerable attention has focused on deciphering the hypothalamic pathways that mediate the behavioral and metabolic effects of leptin. We and others have identified several single gene defects that disrupt the molecules in the leptin-melanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterization of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.
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