Similar articles

• SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.

  Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H.Huang IC, et al.J Biol Chem. 2006 Feb 10;281(6):3198-203. doi: 10.1074/jbc.M508381200. Epub 2005 Dec 8.J Biol Chem. 2006.PMID:16339146Free PMC article.
• Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

  Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S.Glowacka I, et al.J Virol. 2010 Jan;84(2):1198-205. doi: 10.1128/JVI.01248-09. Epub 2009 Oct 28.J Virol. 2010.PMID:19864379Free PMC article.
• The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2.

  Li W, Sui J, Huang IC, Kuhn JH, Radoshitzky SR, Marasco WA, Choe H, Farzan M.Li W, et al.Virology. 2007 Oct 25;367(2):367-74. doi: 10.1016/j.virol.2007.04.035. Epub 2007 Jul 12.Virology. 2007.PMID:17631932Free PMC article.
• Insights from the association of SARS-CoV S-protein with its receptor, ACE2.

  Li W, Choe H, Farzan M.Li W, et al.Adv Exp Med Biol. 2006;581:209-18. doi: 10.1007/978-0-387-33012-9_36.Adv Exp Med Biol. 2006.PMID:17037532Free PMC article.Review.No abstract available.
• Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization.

  Jia HP, Look DC, Hickey M, Shi L, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray PB Jr.Jia HP, et al.Adv Exp Med Biol. 2006;581:479-84. doi: 10.1007/978-0-387-33012-9_85.Adv Exp Med Biol. 2006.PMID:17037581Free PMC article.Review.No abstract available.

Cited by

• An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines.

  Guo Y, He W, Mou H, Zhang L, Chang J, Peng S, Ojha A, Tavora R, Parcells MS, Luo G, Li W, Zhong G, Choe H, Farzan M, Quinlan BD.Guo Y, et al.mBio. 2021 May 11;12(3):e00930-21. doi: 10.1128/mBio.00930-21.mBio. 2021.PMID:33975938Free PMC article.
• Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.

  Huang Y, Yang C, Xu XF, Xu W, Liu SW.Huang Y, et al.Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. doi: 10.1038/s41401-020-0485-4. Epub 2020 Aug 3.Acta Pharmacol Sin. 2020.PMID:32747721Free PMC article.Review.
• The spike protein of SARS-CoV--a target for vaccine and therapeutic development.

  Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S.Du L, et al.Nat Rev Microbiol. 2009 Mar;7(3):226-36. doi: 10.1038/nrmicro2090. Epub 2009 Feb 9.Nat Rev Microbiol. 2009.PMID:19198616Free PMC article.Review.
• Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.

  Gnirss K, Kühl A, Karsten C, Glowacka I, Bertram S, Kaup F, Hofmann H, Pöhlmann S.Gnirss K, et al.Virology. 2012 Mar 1;424(1):3-10. doi: 10.1016/j.virol.2011.11.031. Epub 2012 Jan 4.Virology. 2012.PMID:22222211Free PMC article.
• Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.

  Wang A, Chiou J, Poirion OB, Buchanan J, Valdez MJ, Verheyden JM, Hou X, Kudtarkar P, Narendra S, Newsome JM, Guo M, Faddah DA, Zhang K, Young RE, Barr J, Sajti E, Misra R, Huyck H, Rogers L, Poole C, Whitsett JA, Pryhuber G, Xu Y, Gaulton KJ, Preissl S, Sun X; NHLBI LungMap Consortium.Wang A, et al.Elife. 2020 Nov 9;9:e62522. doi: 10.7554/eLife.62522.Elife. 2020.PMID:33164753Free PMC article.

References

MeSH terms

• Angiotensin-Converting Enzyme 2
• Cathepsin L
• Cathepsins / chemistry
• Cathepsins / physiology*
• Cell Line
• Coronavirus / pathogenicity*
• Cysteine Endopeptidases / chemistry
• Humans
• Membrane Fusion*
• Membrane Glycoproteins / physiology*
• Peptidyl-Dipeptidase A / physiology
• Severe acute respiratory syndrome-related coronavirus / pathogenicity*
• Spike Glycoprotein, Coronavirus
• Viral Envelope Proteins / chemistry
• Viral Envelope Proteins / physiology*

Substances

• Membrane Glycoproteins
• Spike Glycoprotein, Coronavirus
• Viral Envelope Proteins
• Cathepsins
• Peptidyl-Dipeptidase A
• ACE2 protein, human
• Angiotensin-Converting Enzyme 2
• Cysteine Endopeptidases
• CTSL protein, human
• Cathepsin L

Related information

• PubChem Compound
• PubChem Compound (MeSH Keyword)
• PubChem Substance

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Springer

• Miscellaneous

  • NCI CPTAC Assay Portal