The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases
- PMID:16978533
The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases
Abstract
Protein degradation through the ubiquitin-proteasome system is the major pathway of non-lysosomal proteolysis of intracellular proteins. It plays important roles in a variety of fundamental cellular processes such as regulation of cell cycle progression, division, development and differentiation, apoptosis, cell trafficking, and modulation of the immune and inflammatory responses. The central element of this system is the covalent linkage of ubiquitin to targeted proteins, which are then recognized by the 26S proteasome, an adenosine triphosphate-dependent, multi-catalytic protease. Damaged, oxidized, or misfolded proteins as well as regulatory proteins that control many critical cellular functions are among the targets of this degradation process. Aberration of this system leads to the dysregulation of cellular homeostasis and the development of multiple diseases. In this review, we described the basic biochemistry and molecular biology of the ubiquitin-proteasome system, and its complex role in the development of inflammatory and autoimmune diseases. In addition, therapies and potential therapeutic targets related to the ubiquitin-proteasome system are discussed as well.
Similar articles
- Role of the proteasome in ethanol-induced liver pathology.Donohue TM Jr, Cederbaum AI, French SW, Barve S, Gao B, Osna NA.Donohue TM Jr, et al.Alcohol Clin Exp Res. 2007 Sep;31(9):1446-59. doi: 10.1111/j.1530-0277.2007.00454.x.Alcohol Clin Exp Res. 2007.PMID:17760783Review.
- [The ubiquitin-proteasome system: the relationship between protein degradation and human diseases].Amir R, Ciechanover A, Cohen S.Amir R, et al.Harefuah. 2001 Dec;140(12):1172-6, 1229.Harefuah. 2001.PMID:11789303Hebrew.
- The role of the ubiquitin-proteasome system in kidney diseases.Fukasawa H.Fukasawa H.Clin Exp Nephrol. 2012 Aug;16(4):507-17. doi: 10.1007/s10157-012-0643-1. Epub 2012 Jun 9.Clin Exp Nephrol. 2012.PMID:22684356Review.
- Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity.Hegde AN.Hegde AN.Prog Neurobiol. 2004 Aug;73(5):311-57. doi: 10.1016/j.pneurobio.2004.05.005.Prog Neurobiol. 2004.PMID:15312912Review.
- Proteasome inhibition: mechanism of action.DeMartino GN.DeMartino GN.J Natl Compr Canc Netw. 2004 Nov;2 Suppl 4:S5-9.J Natl Compr Canc Netw. 2004.PMID:19791423Review.
Cited by
- Recent Advances in Pyrazole-based Protein Kinase Inhibitors as Emerging Therapeutic Targets.Cetin A.Cetin A.Comb Chem High Throughput Screen. 2024;27(19):2791-2804. doi: 10.2174/0113862073252211231024182817.Comb Chem High Throughput Screen. 2024.PMID:37946345Review.
- Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease.Buraczynska M, Stec A, Filipczak A, Ksiazek A.Buraczynska M, et al.Int Urol Nephrol. 2016 Dec;48(12):2083-2087. doi: 10.1007/s11255-016-1420-y. Epub 2016 Sep 26.Int Urol Nephrol. 2016.PMID:27671905Free PMC article.
- Transcriptome Analysis Reveals the Multiple Functions of pBD2 in IPEC-J2 Cells againstE. coli.Lian S, Lin X, Zhan F, Shen X, Liang Y, Li C.Lian S, et al.Int J Mol Sci. 2022 Aug 28;23(17):9754. doi: 10.3390/ijms23179754.Int J Mol Sci. 2022.PMID:36077151Free PMC article.
- Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus.Liu S, Liu H, Zhang K, Li X, Duan Y, Wang Z, Wang T.Liu S, et al.Virol Sin. 2019 Oct;34(5):572-582. doi: 10.1007/s12250-019-00162-9. Epub 2019 Oct 21.Virol Sin. 2019.PMID:31637631Free PMC article.
- Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1.Boughton AJ, Krueger S, Fushman D.Boughton AJ, et al.Structure. 2020 Jan 7;28(1):29-43.e6. doi: 10.1016/j.str.2019.10.008. Epub 2019 Oct 31.Structure. 2020.PMID:31677892Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical