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Review
.2006:40:187-208.
doi: 10.1146/annurev.genet.40.110405.090428.

Cellular responses to DNA damage: one signal, multiple choices

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Review

Cellular responses to DNA damage: one signal, multiple choices

Tin Tin Su. Annu Rev Genet.2006.

Abstract

DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

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