Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study
- PMID:16740869
- DOI: 10.1542/peds.2005-1919
Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study
Abstract
Objective: Our goal was to assess the effect of episodes of neonatal hypoglycemia on subsequent neurodevelopment.
Methods: We searched Medline and Embase for cohort studies on subsequent neurodevelopment after episodes of hypoglycemia in the first week of life. Reference lists of available studies were reviewed, and content experts were contacted for additional studies. Included studies were selected and appraised for methodologic quality by 2 reviewers. Methodologic quality was assessed according to well-accepted criteria for prognostic studies. Eventually, all studies were given an overall quality score: poor, moderate, or high quality. Studies in the latter 2 categories were considered for quantitative data analysis.
Results: Eighteen eligible studies were identified. The overall methodologic quality of the included studies was considered poor in 16 studies and high in 2 studies. Pooling of results of the 2 high-quality studies was deemed inappropriate because of major clinical and methodologic heterogeneity. None of the studies provided a valid estimate of the effect of neonatal hypoglycemia on neurodevelopment. Building on the strengths and weaknesses of existing studies, we developed a proposal for an "optimal" future study design.
Conclusions: Recommendations for clinical practice cannot be based on valid scientific evidence in this field. To assess the effect of neonatal hypoglycemia on subsequent neurodevelopment, a well-designed prospective study should be undertaken. We submit a design for a study that may answer the still-open questions.
Similar articles
- Telemedicine for the Medicare population: pediatric, obstetric, and clinician-indirect home interventions.Hersh WR, Wallace JA, Patterson PK, Shapiro SE, Kraemer DF, Eilers GM, Chan BK, Greenlick MR, Helfand M.Hersh WR, et al.Evid Rep Technol Assess (Summ). 2001 Aug;(24 Suppl):1-32.Evid Rep Technol Assess (Summ). 2001.PMID:11569328Free PMC article.
- Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].Henderson JT, Whitlock EP, O'Conner E, Senger CA, Thompson JH, Rowland MG.Henderson JT, et al.Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr. Report No.: 14-05207-EF-1.Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr. Report No.: 14-05207-EF-1.PMID:24783270Free Books & Documents.Review.
- Screening for Gestational Diabetes Mellitus [Internet].Hillier TA, Vesco KK, Whitlock EP, Pettitt DJ, Pedula KL, Beil TL.Hillier TA, et al.Rockville (MD): Agency for Healthcare Research and Quality (US); 2008 May. Report No.: 08-05115-EF-1.Rockville (MD): Agency for Healthcare Research and Quality (US); 2008 May. Report No.: 08-05115-EF-1.PMID:20722157Free Books & Documents.Review.
- Approaches to the definition of neonatal hypoglycemia.Sinclair JC.Sinclair JC.Acta Paediatr Jpn. 1997 Apr;39 Suppl 1:S17-20.Acta Paediatr Jpn. 1997.PMID:9200874Review.
- Systematic review of guidelines on neonatal hypoglycemia.Luo K, Tang J, Zhang M, He Y.Luo K, et al.Clin Endocrinol (Oxf). 2024 Jan;100(1):36-49. doi: 10.1111/cen.14995. Epub 2023 Nov 24.Clin Endocrinol (Oxf). 2024.PMID:37997458Review.
Cited by
- Neurocognitive Outcomes at Age 2 Years After Neonatal Hypoglycemia in a Cohort of Participants From the hPOD Randomized Trial.Edwards T, Alsweiler JM, Gamble GD, Griffith R, Lin L, McKinlay CJD, Rogers JA, Thompson B, Wouldes TA, Harding JE.Edwards T, et al.JAMA Netw Open. 2022 Oct 3;5(10):e2235989. doi: 10.1001/jamanetworkopen.2022.35989.JAMA Netw Open. 2022.PMID:36219444Free PMC article.Clinical Trial.
- No Clinically Relevant Memory Effects in Perinatal Hyperglycemia and Hypoglycemia: A 40-Year Follow-Up of a Small Cohort.Järvinen I, Launes J, Lipsanen J, Virta M, Vanninen R, Lehto E, Schiavone N, Tuulio-Henriksson A, Hokkanen L.Järvinen I, et al.Front Public Health. 2022 Jul 1;10:858210. doi: 10.3389/fpubh.2022.858210. eCollection 2022.Front Public Health. 2022.PMID:35844845Free PMC article.
- Neonatal hypoglycemia: is 60 the new 40? The questions remain the same.Adamkin DH, Polin R.Adamkin DH, et al.J Perinatol. 2016 Jan;36(1):10-2. doi: 10.1038/jp.2015.125.J Perinatol. 2016.PMID:26707690Review.No abstract available.
- Standards of admission capillary blood glucose levels in cesarean born neonates.Smolkin T, Ulanovsky I, Carasso P, Makhoul IR.Smolkin T, et al.World J Pediatr. 2017 Oct;13(5):433-438. doi: 10.1007/s12519-017-0016-7. Epub 2017 Feb 14.World J Pediatr. 2017.PMID:28194693
- Hypoglycemia in the newborn.Jain A, Aggarwal R, Jeeva Sankar M, Agarwal R, Deorari AK, Paul VK.Jain A, et al.Indian J Pediatr. 2010 Oct;77(10):1137-42. doi: 10.1007/s12098-010-0175-1. Epub 2010 Sep 7.Indian J Pediatr. 2010.PMID:20821280
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Medical