doi: 10.1016/j.ejphar.2006.04.026. Epub 2006 May 3.
In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors
Affiliations
- PMID:16730695
- DOI: 10.1016/j.ejphar.2006.04.026
Item in Clipboard
In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors
Shaun Jordan et al. Eur J Pharmacol..
Display options
Format
Display options
Format
Abstract
Dopamine potently increased calcium mobilization in Chinese hamster ovary cells expressing human dopamine D2Long receptors (CHO-D2L cells), and increased guanosine-5'-O-(3-[35S]thio)-triphosphate binding to CHO-D2L cell and rat striatal membranes. These effects of dopamine were blocked by the dopamine D2 receptor antagonist (-)raclopride. In contrast to the findings of a recent controversial study, phencyclidine, ketamine and dizocilpine (MK-801) lacked dopamine D2 receptor full agonist, partial agonist and antagonist activity in these assays, suggesting their psychotomimetic effects, and activity in rodent models of schizophrenia, are associated with N-methyl-d-aspartate receptor blockade rather than a direct interaction with dopamine D2 receptors.
Similar articles
- Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling.Jordan S, Johnson JL, Regardie K, Chen R, Koprivica V, Tadori Y, Kambayashi J, Kitagawa H, Kikuchi T.Jordan S, et al.Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):348-56. doi: 10.1016/j.pnpbp.2006.09.007. Epub 2006 Oct 27.Prog Neuropsychopharmacol Biol Psychiatry. 2007.PMID:17070976
- Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5'-O-(gamma-thiotriphosphate) binding in rat striatal membranes.Odagaki Y, Toyoshima R.Odagaki Y, et al.Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1304-12. doi: 10.1016/j.pnpbp.2006.05.007. Epub 2006 Jul 7.Prog Neuropsychopharmacol Biol Psychiatry. 2006.PMID:16824659
- G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study.Newman-Tancredi A, Cussac D, Audinot V, Pasteau V, Gavaudan S, Millan MJ.Newman-Tancredi A, et al.Mol Pharmacol. 1999 Mar;55(3):564-74.Mol Pharmacol. 1999.PMID:10051542
- The N-methyl-D-aspartate receptor and schizophrenia.Strous RD, Javitt DC.Strous RD, et al.Isr J Med Sci. 1996 May;32(5):275-81.Isr J Med Sci. 1996.PMID:8641863Review.No abstract available.
- [Genetic study on schizophrenia and its recurrence utilizing pharmacological models].Nishikawa T.Nishikawa T.Seishin Shinkeigaku Zasshi. 2002;104(6):487-92.Seishin Shinkeigaku Zasshi. 2002.PMID:12373803Review.Japanese.No abstract available.
Cited by
- Neurochemical modulators of sleep and anesthetic states.Van Dort CJ, Baghdoyan HA, Lydic R.Van Dort CJ, et al.Int Anesthesiol Clin. 2008 Summer;46(3):75-104. doi: 10.1097/AIA.0b013e318181a8ca.Int Anesthesiol Clin. 2008.PMID:18617819Free PMC article.Review.No abstract available.
- Functional reactivity of the dopaminergic system following acute and chronic ketamine treatments.Owolabi AR, Akanmu MA, Ukponmwan OE.Owolabi AR, et al.Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):117-24. doi: 10.1007/s00210-008-0283-x. Epub 2008 Apr 12.Naunyn Schmiedebergs Arch Pharmacol. 2008.PMID:18408917
- Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses.Adams WK, Halberstadt AL, van den Buuse M.Adams WK, et al.Front Pharmacol. 2013 Aug 29;4:109. doi: 10.3389/fphar.2013.00109. eCollection 2013.Front Pharmacol. 2013.PMID:24009584Free PMC article.
- Ketamine for treatment-resistant unipolar depression: current evidence.Mathew SJ, Shah A, Lapidus K, Clark C, Jarun N, Ostermeyer B, Murrough JW.Mathew SJ, et al.CNS Drugs. 2012 Mar 1;26(3):189-204. doi: 10.2165/11599770-000000000-00000.CNS Drugs. 2012.PMID:22303887Free PMC article.Review.
- A brief history of the development of antidepressant drugs: from monoamines to glutamate.Hillhouse TM, Porter JH.Hillhouse TM, et al.Exp Clin Psychopharmacol. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550.Exp Clin Psychopharmacol. 2015.PMID:25643025Free PMC article.Review.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources