Hijacking of the host-cell response and translational control during influenza virus infection
- PMID:16630668
- DOI: 10.1016/j.virusres.2005.10.013
Hijacking of the host-cell response and translational control during influenza virus infection
Abstract
Influenza virus is a major public health problem with annual deaths in the US of 36,000 with pandemic outbreaks, such as in 1918, resulting in deaths exceeding 20 million worldwide. Recently, there is much concern over the introduction of highly pathogenic avian influenza H5N1 viruses into the human population. Influenza virus has evolved complex translational control strategies that utilize cap-dependent translation initiation mechanisms and involve the recruitment of both viral and host-cell proteins to preferentially synthesize viral proteins and prevent activation of antiviral responses. Influenza virus is a member of the Orthomyxoviridae family of negative-stranded, segmented RNA viruses and represents a particularly attractive model system as viral replication strategies are closely intertwined with normal cellular processes including the host defense and stress pathways. In this chapter, we review the parallels between translational control in influenza virus infected cells and in stressed cells with a focus on selective translation of viral mRNAs and the antagonism of the dsRNA and host antiviral responses. Moreover, we will discuss how the use of genomic technologies such as DNA microarrays and high through-put proteomics can be used to gain new insights into the control of protein synthesis during viral infection and provide a near comprehensive view of virus-host interactions.
Similar articles
- What happens inside lentivirus or influenza virus infected cells: insights into regulation of cellular and viral protein synthesis.Gale M Jr, Katze MG.Gale M Jr, et al.Methods. 1997 Apr;11(4):383-401. doi: 10.1006/meth.1996.0436.Methods. 1997.PMID:9126553
- So similar, yet so different: selective translation of capped and polyadenylated viral mRNAs in the influenza virus infected cell.Yángüez E, Nieto A.Yángüez E, et al.Virus Res. 2011 Mar;156(1-2):1-12. doi: 10.1016/j.virusres.2010.12.016. Epub 2010 Dec 31.Virus Res. 2011.PMID:21195735Review.
- Host cellular signaling induced by influenza virus.Dai X, Zhang L, Hong T.Dai X, et al.Sci China Life Sci. 2011 Jan;54(1):68-74. doi: 10.1007/s11427-010-4116-z. Epub 2011 Jan 21.Sci China Life Sci. 2011.PMID:21253874
- Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines.Vester D, Rapp E, Gade D, Genzel Y, Reichl U.Vester D, et al.Proteomics. 2009 Jun;9(12):3316-27. doi: 10.1002/pmic.200800893.Proteomics. 2009.PMID:19504497
- Phosphorylation and dephosphorylation events that regulate viral mRNA translation.Mohr I.Mohr I.Virus Res. 2006 Jul;119(1):89-99. doi: 10.1016/j.virusres.2005.10.009. Epub 2005 Nov 21.Virus Res. 2006.PMID:16305812Review.
Cited by
- Moving H5N1 studies into the era of systems biology.Josset L, Tisoncik-Go J, Katze MG.Josset L, et al.Virus Res. 2013 Dec 5;178(1):151-67. doi: 10.1016/j.virusres.2013.02.011. Epub 2013 Mar 14.Virus Res. 2013.PMID:23499671Free PMC article.Review.
- Response of primary human airway epithelial cells to influenza infection: a quantitative proteomic study.Kroeker AL, Ezzati P, Halayko AJ, Coombs KM.Kroeker AL, et al.J Proteome Res. 2012 Aug 3;11(8):4132-46. doi: 10.1021/pr300239r. Epub 2012 Jul 2.J Proteome Res. 2012.PMID:22694362Free PMC article.
- The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism.Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas MJ, Korth MJ, Barber GN, Schiff LA, Katze MG.Goodman AG, et al.J Virol. 2007 Mar;81(5):2221-30. doi: 10.1128/JVI.02151-06. Epub 2006 Dec 13.J Virol. 2007.PMID:17166899Free PMC article.
- Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus.Richards KA, Chaves FA, Sant AJ.Richards KA, et al.J Virol. 2009 Jul;83(13):6566-77. doi: 10.1128/JVI.00302-09. Epub 2009 Apr 22.J Virol. 2009.PMID:19386707Free PMC article.
- Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells.Tong M, Yi L, Sun N, Cheng Y, Cao Z, Wang J, Li S, Lin P, Sun Y, Cheng S.Tong M, et al.Front Microbiol. 2017 Dec 22;8:2564. doi: 10.3389/fmicb.2017.02564. eCollection 2017.Front Microbiol. 2017.PMID:29312244Free PMC article.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous