René Dubos: unearthing antibiotics
- PMID:16528813
- PMCID: PMC2118194
- DOI: 10.1084/jem.2032fta
René Dubos: unearthing antibiotics
Abstract
In 1939, René Dubos discovered gramicidin-the first clinically tested antibiotic agent. This discovery helped revive the stalled interest in penicillin and launched the era of antibiotics.
Figures
Similar articles
- Antibiotic antagonist: the curious career of René Dubos.Honigsbaum M.Honigsbaum M.Lancet. 2016 Jan 9;387(10014):118-9. doi: 10.1016/S0140-6736(15)00840-5. Epub 2015 Nov 18.Lancet. 2016.PMID:26841989Free PMC article.No abstract available.
- The discovery of Gramicidin S: the intellectual transformation of G.F. Gause from biologist to researcher of antibiotics and on its meaning for the fate of Russian genetics.Gall YM, Konashev MB.Gall YM, et al.Hist Philos Life Sci. 2001;23(1):137-50.Hist Philos Life Sci. 2001.PMID:12212443
- [History of antibiotics and sulphonamides discoveries].Jeśman C, Młudzik A, Cybulska M.Jeśman C, et al.Pol Merkur Lekarski. 2011 May;30(179):320-2.Pol Merkur Lekarski. 2011.PMID:21675132Review.Polish.
- THE CLASSIC: penicillin as a chemotherapeutic agent. 1940.Chain E, Florey HW, Gardner AD, Heatley NG, Jennings MA, Orr-Ewing J, Sanders AG.Chain E, et al.Clin Orthop Relat Res. 2005 Oct;439:23-6. doi: 10.1097/01.blo.0000183429.83168.07.Clin Orthop Relat Res. 2005.PMID:16205132No abstract available.
- History of Antibiotics Research.Mohr KI.Mohr KI.Curr Top Microbiol Immunol. 2016;398:237-272. doi: 10.1007/82_2016_499.Curr Top Microbiol Immunol. 2016.PMID:27738915Review.
Cited by
- Antimicrobial Peptides: the Achilles' Heel of Antibiotic Resistance?Lewies A, Du Plessis LH, Wentzel JF.Lewies A, et al.Probiotics Antimicrob Proteins. 2019 Jun;11(2):370-381. doi: 10.1007/s12602-018-9465-0.Probiotics Antimicrob Proteins. 2019.PMID:30229514Review.
- In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens.Khabthani S, Rolain JM, Merhej V.Khabthani S, et al.Microorganisms. 2021 Nov 5;9(11):2297. doi: 10.3390/microorganisms9112297.Microorganisms. 2021.PMID:34835423Free PMC article.Review.
- Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides.Rodríguez AA, Otero-González A, Ghattas M, Ständker L.Rodríguez AA, et al.Biomedicines. 2021 Oct 3;9(10):1381. doi: 10.3390/biomedicines9101381.Biomedicines. 2021.PMID:34680498Free PMC article.Review.
- Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields.Moretta A, Scieuzo C, Petrone AM, Salvia R, Manniello MD, Franco A, Lucchetti D, Vassallo A, Vogel H, Sgambato A, Falabella P.Moretta A, et al.Front Cell Infect Microbiol. 2021 Jun 14;11:668632. doi: 10.3389/fcimb.2021.668632. eCollection 2021.Front Cell Infect Microbiol. 2021.PMID:34195099Free PMC article.Review.
- The current landscape of the antimicrobial peptide melittin and its therapeutic potential.Zhang HQ, Sun C, Xu N, Liu W.Zhang HQ, et al.Front Immunol. 2024 Jan 22;15:1326033. doi: 10.3389/fimmu.2024.1326033. eCollection 2024.Front Immunol. 2024.PMID:38318188Free PMC article.Review.
References
- Moberg, C.L. 2005. René Dubos: Friend of the good earth. ASM Press. Washington, DC.
- Avery, O.T., and R. Dubos. 1930. Science. 72:151–152. - PubMed
- Goodner, K., F.L. Horsfall, and R. Dubos. 1937. J. Immunol. 33:279–295.
Publication types
MeSH terms
Substances
Personal name as subject
- Actions
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical