The ubiquitin-proteasome system in cardiac physiology and pathology
- PMID:16501026
- DOI: 10.1152/ajpheart.00062.2006
The ubiquitin-proteasome system in cardiac physiology and pathology
Abstract
The ubiquitin-proteasome system (UPS) is the major nonlysosomal pathway for intracellular protein degradation, generally requiring a covalent linkage of one or more chains of polyubiquitins to the protein intended for degradation. It has become clear that the UPS plays major roles in regulating many cellular processes, including the cell cycle, immune responses, apoptosis, cell signaling, and protein turnover under normal and pathological conditions, as well as in protein quality control by removal of damaged, oxidized, and/or misfolded proteins. This review will present an overview of the structure, biochemistry, and physiology of the UPS with emphasis on its role in the heart, if known. In addition, evidence will be presented supporting the role of certain muscle-specific ubiquitin protein ligases, key regulatory components of the UPS, in regulation of sarcomere protein turnover and cardiomyocyte size and how this might play a role in induction of the hypertrophic phenotype. Moreover, this review will present the evidence suggesting that proteasomal dysfunction may play a role in cardiac pathologies such as myocardial ischemia, congestive heart failure, and myofilament-related and idiopathic-dilated cardiomyopathies, as well as cardiomyocyte loss in the aging heart. Finally, certain pitfalls of proteasome studies will be described with the intent of providing investigators with enough information to avoid these problems. This review should provide current investigators in the field with an up-to-date analysis of the literature and at the same time provide an impetus for new investigators to enter this important and rapidly changing area of research.
Similar articles
- The role of ubiquitin ligases in cardiac disease.Willis MS, Bevilacqua A, Pulinilkunnil T, Kienesberger P, Tannu M, Patterson C.Willis MS, et al.J Mol Cell Cardiol. 2014 Jun;71:43-53. doi: 10.1016/j.yjmcc.2013.11.008. Epub 2013 Nov 19.J Mol Cell Cardiol. 2014.PMID:24262338Free PMC article.Review.
- The ubiquitin-proteasome system: focus on the heart.Zolk O, Schenke C, Sarikas A.Zolk O, et al.Cardiovasc Res. 2006 Jun 1;70(3):410-21. doi: 10.1016/j.cardiores.2005.12.021. Epub 2006 Feb 23.Cardiovasc Res. 2006.PMID:16497285Review.
- Into the heart: the emerging role of the ubiquitin-proteasome system.Willis MS, Patterson C.Willis MS, et al.J Mol Cell Cardiol. 2006 Oct;41(4):567-79. doi: 10.1016/j.yjmcc.2006.07.015. Epub 2006 Sep 1.J Mol Cell Cardiol. 2006.PMID:16949602Review.
- Ubiquitin-proteasome system and hereditary cardiomyopathies.Schlossarek S, Frey N, Carrier L.Schlossarek S, et al.J Mol Cell Cardiol. 2014 Jun;71:25-31. doi: 10.1016/j.yjmcc.2013.12.016. Epub 2013 Dec 28.J Mol Cell Cardiol. 2014.PMID:24380728Review.
- The bitter end: the ubiquitin-proteasome system and cardiac dysfunction.Patterson C, Ike C, Willis PW 4th, Stouffer GA, Willis MS.Patterson C, et al.Circulation. 2007 Mar 20;115(11):1456-63. doi: 10.1161/CIRCULATIONAHA.106.649863.Circulation. 2007.PMID:17372187Review.
Cited by
- Myosin light chain phosphorylation is critical for adaptation to cardiac stress.Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupin-Furlowe J, McMullen JR, Moss RL, Kasahara H.Warren SA, et al.Circulation. 2012 Nov 27;126(22):2575-88. doi: 10.1161/CIRCULATIONAHA.112.116202. Epub 2012 Oct 24.Circulation. 2012.PMID:23095280Free PMC article.
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.Picca A, Mankowski RT, Burman JL, Donisi L, Kim JS, Marzetti E, Leeuwenburgh C.Picca A, et al.Nat Rev Cardiol. 2018 Sep;15(9):543-554. doi: 10.1038/s41569-018-0059-z.Nat Rev Cardiol. 2018.PMID:30042431Free PMC article.Review.
- Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus.Lu T, Lee HC.Lu T, et al.Front Physiol. 2021 Oct 21;12:750618. doi: 10.3389/fphys.2021.750618. eCollection 2021.Front Physiol. 2021.PMID:34744789Free PMC article.Review.
- Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion.Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF, Sadoshima J.Matsui Y, et al.Autophagy. 2008 May;4(4):409-15. doi: 10.4161/auto.5638. Epub 2008 Jan 24.Autophagy. 2008.PMID:18227645Free PMC article.Review.
- The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease.Goto J, Otaki Y, Watanabe T, Watanabe M.Goto J, et al.Int J Mol Sci. 2021 Jun 4;22(11):6065. doi: 10.3390/ijms22116065.Int J Mol Sci. 2021.PMID:34199773Free PMC article.Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical