doi: 10.1126/science.1122689. Epub 2006 Feb 16.
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
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- PMID:16484454
- DOI: 10.1126/science.1122689
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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
Antonio J Giraldez et al. Science..
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Abstract
MicroRNAs (miRNAs) comprise 1 to 3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. By using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target messenger RNA molecules (mRNAs). Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.
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- Developmental biology. Mixed messages in early development.Cohen SM, Brennecke J.Cohen SM, et al.Science. 2006 Apr 7;312(5770):65-6. doi: 10.1126/science.1126400.Science. 2006.PMID:16601183No abstract available.
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