Review
doi: 10.1016/j.tins.2006.01.002. Epub 2006 Jan 27.Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it?
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- PMID:16443286
- DOI: 10.1016/j.tins.2006.01.002
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Review
Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it?
Yuri Bozzi et al. Trends Neurosci.2006 Mar.
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Abstract
Accurate control of dopamine levels and/or the resulting dopamine-receptor interaction is essential for brain function. Indeed, several human neurological and psychiatric disorders are characterized by dysfunctions of the dopaminergic system. Dopamine has been reported to exert either protective or toxic effects on neurons, yet it is unclear whether these effects are receptor-dependent and, if so, which dopamine receptor could be involved. The D(2) dopamine receptor occupies a privileged position because its signalling might be neuroprotective in human diseases, such as Parkinson's disease, ischaemia and epilepsy. Unravelling the role of D(2) receptors in neuronal death and survival might be central to understanding the mechanisms that underlie several neuropathologies.
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