The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians
- PMID:16418740
- DOI: 10.1038/sj.ejhg.5201552
The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians
Abstract
Low concentrations of adiponectin, the protein product of the APM1 gene, have been reported to be associated with obesity and insulin resistance. However, contrasting results have been described on the genetic variability in APM1 and characteristics of the metabolic syndrome and adiponectin serum concentrations. In the present study, we investigated the association of the two most well-known SNPs of APM1 (+45T>G and +276G>T) and their haplotypes, with serum adiponectin concentrations, metabolic parameters and intima-media thickness of the carotid arteries in 1,745 well-phenotyped asymptomatic unrelated Caucasian subjects of the SAPHIR cohort. The common T-allele (88.5%) of SNP +45T>G and the common G-allele (70.5%) of SNP +276G>T were associated with significantly lower serum adiponectin levels (P = 0.0008 and P = 0.00005, respectively). The most frequent haplotype TG (59.0%) defined by both loci showed a strong association with lower serum adiponectin concentrations (P = 0.000000002). A clear effect per copy of the respective haplotype was observed. This association was most pronounced in lean and insulin-sensitive subjects. The two less common haplotypes TT (29.5%) and GG (11.5%) were associated with higher serum adiponectin levels in a dose-dependent association. Interestingly, no significant association between the adiponectin 45-276 haplotypes and the majority of parameters of the metabolic syndrome or intima-media thickness of the carotid arteries was found in our study. In summary, we replicated a strong association of the adiponectin 45-276 genotypes and haplotypes with adiponectin levels in healthy Caucasians. However, we could not confirm an association of this gene locus with metabolic parameters of the insulin resistance syndrome.
Similar articles
- The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.Jang Y, Chae JS, Koh SJ, Hyun YJ, Kim JY, Jeong YJ, Park S, Ahn CM, Lee JH.Jang Y, et al.Clin Chim Acta. 2008 May;391(1-2):85-90. doi: 10.1016/j.cca.2008.02.011. Epub 2008 Feb 16.Clin Chim Acta. 2008.PMID:18328815
- A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome.Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A.Menzaghi C, et al.Diabetes. 2002 Jul;51(7):2306-12. doi: 10.2337/diabetes.51.7.2306.Diabetes. 2002.PMID:12086965
- Haplotype TGTG from SNP 45T/G and 276G/T of the adiponectin gene contributes to risk of polycystic ovary syndrome.Radavelli-Bagatini S, de Oliveira IO, Ramos RB, Santos BR, Wagner MS, Lecke SB, Gigante DP, Horta BL, Spritzer PM.Radavelli-Bagatini S, et al.J Endocrinol Invest. 2013 Jul-Aug;36(7):497-502. doi: 10.3275/8966. Epub 2013 May 20.J Endocrinol Invest. 2013.PMID:23685884
- The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity.Petrone A, Zavarella S, Caiazzo A, Leto G, Spoletini M, Potenziani S, Osborn J, Vania A, Buzzetti R.Petrone A, et al.Obesity (Silver Spring). 2006 Sep;14(9):1498-504. doi: 10.1038/oby.2006.172.Obesity (Silver Spring). 2006.PMID:17030959
- Association between the adiponectin +45T>G genotype and risk of cardiovascular disease: a meta-analysis.Zhou D, Jin Y, Yao F, Duan Z, Wang Q, Liu J.Zhou D, et al.Heart Lung Circ. 2014 Feb;23(2):159-65. doi: 10.1016/j.hlc.2013.07.010. Epub 2013 Aug 21.Heart Lung Circ. 2014.PMID:23972466Review.
Cited by
- ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women.Cohen SS, Gammon MD, North KE, Millikan RC, Lange EM, Williams SM, Zheng W, Cai Q, Long J, Smith JR, Signorello LB, Blot WJ, Matthews CE.Cohen SS, et al.Obesity (Silver Spring). 2011 Oct;19(10):2053-62. doi: 10.1038/oby.2010.346. Epub 2011 Jan 27.Obesity (Silver Spring). 2011.PMID:21273992Free PMC article.
- Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort.Riestra P, Gebreab SY, Xu R, Khan RJ, Bidulescu A, Correa A, Tekola-Ayele F, Davis SK.Riestra P, et al.BMC Med Genet. 2015 Aug 20;16:65. doi: 10.1186/s12881-015-0214-x.BMC Med Genet. 2015.PMID:26290432Free PMC article.
- Amerindians show association to obesity with adiponectin gene SNP45 and SNP276: population genetics of a food intake control and "thrifty" gene.Arnaiz-Villena A, Fernández-Honrado M, Rey D, Enríquez-de-Salamanca M, Abd-El-Fatah-Khalil S, Arribas I, Coca C, Algora M, Areces C.Arnaiz-Villena A, et al.Mol Biol Rep. 2013 Feb;40(2):1819-26. doi: 10.1007/s11033-012-2236-1. Epub 2012 Oct 30.Mol Biol Rep. 2013.PMID:23108996
- Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population.Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.Tanimura D, et al.Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.Eur J Hum Genet. 2011.PMID:21150884Free PMC article.
- A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome.Peters KE, Beilby J, Cadby G, Warrington NM, Bruce DG, Davis WA, Davis TM, Wiltshire S, Knuiman M, McQuillan BM, Palmer LJ, Thompson PL, Hung J.Peters KE, et al.BMC Med Genet. 2013 Jan 25;14:15. doi: 10.1186/1471-2350-14-15.BMC Med Genet. 2013.PMID:23351195Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous