Good cop, bad cop: the different faces of NF-kappaB
- PMID:16410803
- DOI: 10.1038/sj.cdd.4401838
Good cop, bad cop: the different faces of NF-kappaB
Abstract
Complexes formed from the nuclear factor kappaB (NF-kappaB) family of transcription factors are ubiquitously expressed and are induced by a diverse array of stimuli. This results in their becoming activated in a wide variety of different settings. While the functions of NF-kappaB in many of these contexts have been the subject of intense research and are now well established, it is also clear that there is great diversity in the effects and consequences of NF-kappaB activation. NF-kappaB subunits do not necessarily regulate the same genes, in an identical manner, in all of the different circumstances in which they are induced. This review will discuss the different functions of NF-kappaB, the pathways that modulate NF-kappaB subunit activity and, in contrast to its more commonly thought of role as a promoter of cancer cell growth and survival, the ability of NF-kappaB, under some circumstances, to behave as a tumor suppressor.
Similar articles
- Regulation and function of IKK and IKK-related kinases.Häcker H, Karin M.Häcker H, et al.Sci STKE. 2006 Oct 17;2006(357):re13. doi: 10.1126/stke.3572006re13.Sci STKE. 2006.PMID:17047224Review.
- NF-kappaB: tumor promoter or suppressor?Perkins ND.Perkins ND.Trends Cell Biol. 2004 Feb;14(2):64-9. doi: 10.1016/j.tcb.2003.12.004.Trends Cell Biol. 2004.PMID:15102437Review.
- NF-kappaB and IKK as therapeutic targets in cancer.Kim HJ, Hawke N, Baldwin AS.Kim HJ, et al.Cell Death Differ. 2006 May;13(5):738-47. doi: 10.1038/sj.cdd.4401877.Cell Death Differ. 2006.PMID:16485028Review.
- The role of ubiquitin in NF-kappaB regulatory pathways.Skaug B, Jiang X, Chen ZJ.Skaug B, et al.Annu Rev Biochem. 2009;78:769-96. doi: 10.1146/annurev.biochem.78.070907.102750.Annu Rev Biochem. 2009.PMID:19489733Review.
- Ras effector pathways modulate scatter factor-stimulated NF-kappaB signaling and protection against DNA damage.Fan S, Meng Q, Laterra JJ, Rosen EM.Fan S, et al.Oncogene. 2007 Jul 19;26(33):4774-96. doi: 10.1038/sj.onc.1210271. Epub 2007 Feb 12.Oncogene. 2007.PMID:17297451
Cited by
- Oxidative Stress, Plant Natural Antioxidants, and Obesity.Pérez-Torres I, Castrejón-Téllez V, Soto ME, Rubio-Ruiz ME, Manzano-Pech L, Guarner-Lans V.Pérez-Torres I, et al.Int J Mol Sci. 2021 Feb 11;22(4):1786. doi: 10.3390/ijms22041786.Int J Mol Sci. 2021.PMID:33670130Free PMC article.Review.
- Nuclear Factor-Kappa-B Mediates the Advanced Glycation End Product-Induced Repression ofSlc2a4 Gene Expression in 3T3-L1 Adipocytes.Michalani MLE, Passarelli M, Machado UF.Michalani MLE, et al.Int J Mol Sci. 2024 Jul 28;25(15):8242. doi: 10.3390/ijms25158242.Int J Mol Sci. 2024.PMID:39125811Free PMC article.
- TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling.Kenneth NS, Mudie S, Naron S, Rocha S.Kenneth NS, et al.Biochem J. 2013 Jan 1;449(1):275-84. doi: 10.1042/BJ20120625.Biochem J. 2013.PMID:23016877Free PMC article.
- Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.Aksenova V, et al.Oncotarget. 2013 Feb;4(2):362-72. doi: 10.18632/oncotarget.901.Oncotarget. 2013.PMID:23482348Free PMC article.
- Immune cells and immune cell-targeted therapy in chronic pancreatitis.Zhang Y, Zhang WQ, Liu XY, Zhang Q, Mao T, Li XY.Zhang Y, et al.Front Oncol. 2023 Mar 9;13:1151103. doi: 10.3389/fonc.2023.1151103. eCollection 2023.Front Oncol. 2023.PMID:36969002Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials