Systemic markers of inflammation in periodontitis
- PMID:16277583
- DOI: 10.1902/jop.2005.76.11-S.2106
Systemic markers of inflammation in periodontitis
Abstract
This literature review summarizes current knowledge on the systemic levels of selected markers of inflammation in periodontitis. From samples of peripheral blood the following cellular factors are discussed: total number of white blood cells, red blood cells, and thrombocytes. Further, plasma levels of acute-phase proteins, cytokines, and coagulation factors are reviewed. From the available literature it appears that the total numbers of leukocytes and plasma levels of C-reactive protein are consistently higher in periodontitis patients compared to healthy controls. Numbers of red blood cells and levels of hemoglobin are lower in periodontitis and there is a trend towards anemia of chronic disease. Most systemic markers of inflammation discussed in this review are also regarded as predictive markers for cardiovascular diseases. Therefore, changes in these markers in periodontitis may be part of the explanation why periodontitis is associated with cardiovascular diseases and/or cerebrovascular events in epidemiological studies. It is hypothesized that possibly daily episodes of a bacteremia originating from periodontal lesions are the cause for the changes in systemic markers in periodontitis; the cumulative size of all periodontal lesions in the untreated severe patient may amount to 15 to 20 cm2.
Similar articles
- Systemic effects of periodontitis.Loos BG.Loos BG.Ann R Australas Coll Dent Surg. 2006 Sep;18:27-9.Ann R Australas Coll Dent Surg. 2006.PMID:17668587Review.
- Systemic Markers of Inflammation in Periodontitis.Loos BG.Loos BG.J Periodontol. 2005 Nov;76 Suppl 11S:2106-2115. doi: 10.1902/jop.2005.76.11-S.2106.J Periodontol. 2005.PMID:29539043
- The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial.Taylor B, Tofler G, Morel-Kopp MC, Carey H, Carter T, Elliott M, Dailey C, Villata L, Ward C, Woodward M, Schenck K.Taylor B, et al.Eur J Oral Sci. 2010 Aug;118(4):350-6. doi: 10.1111/j.1600-0722.2010.00748.x.Eur J Oral Sci. 2010.PMID:20662907Clinical Trial.
- Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis.Sun XJ, Meng HX, Shi D, Xu L, Zhang L, Chen ZB, Feng XH, Lu RF, Ren XY.Sun XJ, et al.J Periodontal Res. 2009 Jun;44(3):311-6. doi: 10.1111/j.1600-0765.2008.01131.x. Epub 2008 Oct 7.J Periodontal Res. 2009.PMID:18842114
- Periodontal therapy and biomarkers related to cardiovascular risk.Moura Foz A, Alexandre Romito G, Manoel Bispo C, Luciancencov Petrillo C, Patel K, Suvan J, D'Aiuto F.Moura Foz A, et al.Minerva Stomatol. 2010 May;59(5):271-83.Minerva Stomatol. 2010.PMID:20502435Review.
Cited by
- Pocket depth and bleeding on probing and their associations with dental, lifestyle, socioeconomic and blood variables: a cross-sectional, multicenter feasibility study of the German National Cohort.Zimmermann H, Hagenfeld D, Diercke K, El-Sayed N, Fricke J, Greiser KH, Kühnisch J, Linseisen J, Meisinger C, Pischon N, Pischon T, Samietz S, Schmitter M, Steinbrecher A, Kim TS, Becher H.Zimmermann H, et al.BMC Oral Health. 2015 Jan 21;15:7. doi: 10.1186/1472-6831-15-7.BMC Oral Health. 2015.PMID:25604448Free PMC article.
- Better Oral Hygiene Is Associated with a Decreased Risk of Meniere's Disease: A Nationwide Cohort Study.Park JH, Kim JW, Lee H, Hong I, Song TJ.Park JH, et al.J Pers Med. 2022 Dec 29;13(1):80. doi: 10.3390/jpm13010080.J Pers Med. 2022.PMID:36675740Free PMC article.
- Does oral lichen planus aggravate the state of periodontal disease? A systematic review and meta-analysis.Nunes GP, Pirovani BO, Nunes LP, Silva ANA, Morábito MJSD, Nunes-Júnior NA, Delbem ACB, Ferrisse TM.Nunes GP, et al.Clin Oral Investig. 2022 Apr;26(4):3357-3371. doi: 10.1007/s00784-022-04387-z. Epub 2022 Feb 8.Clin Oral Investig. 2022.PMID:35132470Review.
- Markers, Pathways, and Current Evidence for Periodontitis-associated Insulin Resistance: A Narrative Review.Bains VK, Mahendra J, Mahendra L, Mittal M, Valli G.Bains VK, et al.J Int Soc Prev Community Dent. 2022 Oct 31;12(5):475-487. doi: 10.4103/jispcd.JISPCD_92_22. eCollection 2022 Sep-Oct.J Int Soc Prev Community Dent. 2022.PMID:36532318Free PMC article.Review.
- Association of oral health with lung cancer risk in a low-income population of African Americans and European Americans in the Southeastern United States.Yoon HS, Wen W, Long J, Zheng W, Blot WJ, Cai Q.Yoon HS, et al.Lung Cancer. 2019 Jan;127:90-95. doi: 10.1016/j.lungcan.2018.11.028. Epub 2018 Nov 23.Lung Cancer. 2019.PMID:30642558Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials