Review
doi: 10.1038/laban1105-47.A review of tribromoethanol anesthesia for production of genetically engineered mice and rats
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- PMID:16261153
- DOI: 10.1038/laban1105-47
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Review
A review of tribromoethanol anesthesia for production of genetically engineered mice and rats
Robert E Meyer et al. Lab Anim (NY).2005 Nov.
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Abstract
Tribromoethanol (TBE) is easy and inexpensive to make in the laboratory from readily available reagents, requires no special equipment for its administration, and is not subject to federal or state drug enforcement agency regulations. Intraperitoneal (i.p.) injection of TBE results in the simple and rapid induction of short-term surgical anesthesia; however, recent adverse reports about the efficacy and safety of TBE make its continued routine use as a rodent anesthetic controversial. The authors review the history and use of TBE as an animal anesthetic and conclude that TBE should be relegated to acute terminal studies when administered i.p.
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