Review
doi: 10.1152/physrev.00003.2005.Mammalian G proteins and their cell type specific functions
Affiliations
- PMID:16183910
- DOI: 10.1152/physrev.00003.2005
Item in Clipboard
Review
Mammalian G proteins and their cell type specific functions
Nina Wettschureck et al. Physiol Rev.2005 Oct.
Free article Display options
Format
Display options
Format
Abstract
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple subforms of G proteins together with receptors, effectors, and various regulatory proteins represent the components of a highly versatile signal transduction system. G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. In this review, some of the functions of heterotrimeric G proteins in defined cells and tissues are described.
Similar articles
- Organization of transmembrane signalling by heterotrimeric G proteins.Offermanns S, Simon MI.Offermanns S, et al.Cancer Surv. 1996;27:177-98.Cancer Surv. 1996.PMID:8909801Review.
- Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques.Hébert TE, Galés C, Rebois RV.Hébert TE, et al.Cell Biochem Biophys. 2006;45(1):85-109. doi: 10.1385/CBB:45:1:85.Cell Biochem Biophys. 2006.PMID:16679566Review.
- G protein signaling: insights from new structures.Preininger AM, Hamm HE.Preininger AM, et al.Sci STKE. 2004 Jan 27;2004(218):re3. doi: 10.1126/stke.2182004re3.Sci STKE. 2004.PMID:14762218Review.
- G-protein regulatory pathways: rocketing into the twenty-first century.Knall C, Johnson GL.Knall C, et al.J Cell Biochem Suppl. 1998;30-31:137-46.J Cell Biochem Suppl. 1998.PMID:9893265Review.
- In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.Offermanns S.Offermanns S.Oncogene. 2001 Mar 26;20(13):1635-42. doi: 10.1038/sj.onc.1204189.Oncogene. 2001.PMID:11313911Review.
Cited by
- The Role of Mitochondrial Enzymes, Succinate-Coupled Signaling Pathways and Mitochondrial Ultrastructure in the Formation of Urgent Adaptation to Acute Hypoxia in the Myocardium.Germanova E, Khmil N, Pavlik L, Mikheeva I, Mironova G, Lukyanova L.Germanova E, et al.Int J Mol Sci. 2022 Nov 17;23(22):14248. doi: 10.3390/ijms232214248.Int J Mol Sci. 2022.PMID:36430733Free PMC article.
- Genome-wide identification of Gα family in grass carp (Ctenopharyngodon idella) and reproductive regulation functional characteristics of Cignaq.Wang C, Xiong S, Hu S, Yang L, Huang Y, Chen H, Xu B, Xiao T, Liu Q.Wang C, et al.BMC Genomics. 2024 Aug 24;25(1):800. doi: 10.1186/s12864-024-10717-0.BMC Genomics. 2024.PMID:39182029Free PMC article.
- MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.Rasheed SAK, Teo CR, Beillard EJ, Voorhoeve PM, Casey PJ.Rasheed SAK, et al.J Biol Chem. 2013 Mar 15;288(11):7986-7995. doi: 10.1074/jbc.M112.437749. Epub 2013 Jan 17.J Biol Chem. 2013.PMID:23329838Free PMC article.
- Heterotrimeric G protein subunits differentially respond to endoplasmic reticulum stress in Arabidopsis.Cho Y, Yu CY, Iwasa T, Kanehara K.Cho Y, et al.Plant Signal Behav. 2015;10(10):e1061162. doi: 10.1080/15592324.2015.1061162. Epub 2015 Aug 3.Plant Signal Behav. 2015.PMID:26237103Free PMC article.
- Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.Sarria I, Pahlberg J, Cao Y, Kolesnikov AV, Kefalov VJ, Sampath AP, Martemyanov KA.Sarria I, et al.Elife. 2015 Apr 16;4:e06358. doi: 10.7554/eLife.06358.Elife. 2015.PMID:25879270Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources