Review
doi: 10.4161/cc.4.8.1900. Epub 2005 Aug 7.p53 proteasomal degradation: poly-ubiquitination is not the whole story
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- PMID:16082197
- DOI: 10.4161/cc.4.8.1900
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Review
p53 proteasomal degradation: poly-ubiquitination is not the whole story
Gad Asher et al. Cell Cycle.2005 Aug.
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Abstract
Protein degradation is a key cellular process involved in almost every aspect of the living cell. The current prevailing concept is that proteins are stable unless marked by poly-ubiquitination for degradation by the proteasomes. Studies on the tumor suppressor p53 have indeed demonstrated that poly-ubiquitination of p53 by different E3 ubiquin ligases targets p53 for degradation by the 26S proteasomes. Recent findings suggest that p53 also undergoes ubiquitin-independent degradation by the 20S proteasomes and that this process is regulated by NAD(P)H quinone oxidoreductase 1 (NQO1) together with NADH. This "degradation by default" mechanism sheds new light on our understanding of p53 degradation and possibly on protein degradation in general and may establish a new principle in protein stability with wide physiological implications.
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