Review
doi: 10.1007/s00018-005-5160-x.The catalytic triad of serine peptidases
Affiliations
- PMID:16003488
- PMCID: PMC11139141
- DOI: 10.1007/s00018-005-5160-x
Item in Clipboard
Review
The catalytic triad of serine peptidases
L Polgár. Cell Mol Life Sci.2005 Oct.
Display options
Format
Display options
Format
Abstract
The catalytic action of serine peptidases depends on the interplay of a nucleophile, a general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is composed of serine, histidine and aspartic acid residues and exhibits similar spatial arrangements, but the order of the residues in the amino acid sequence is different. By now several new families have been discovered, in which the nucleophile-base-acid pattern is generally conserved, but the individual components can vary. The variations illustrate how different groups and different protein structures achieve the same reaction.
Similar articles
- Catalytic triads and their relatives.Dodson G, Wlodawer A.Dodson G, et al.Trends Biochem Sci. 1998 Sep;23(9):347-52. doi: 10.1016/s0968-0004(98)01254-7.Trends Biochem Sci. 1998.PMID:9787641Review.
- NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases.Denesyuk AI, Johnson MS, Salo-Ahen OMH, Uversky VN, Denessiouk K.Denesyuk AI, et al.Int J Biol Macromol. 2020 Jun 15;153:399-411. doi: 10.1016/j.ijbiomac.2020.03.025. Epub 2020 Mar 6.Int J Biol Macromol. 2020.PMID:32151723Free PMC article.
- Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration.Ekici OD, Paetzel M, Dalbey RE.Ekici OD, et al.Protein Sci. 2008 Dec;17(12):2023-37. doi: 10.1110/ps.035436.108. Epub 2008 Sep 29.Protein Sci. 2008.PMID:18824507Free PMC article.Review.
- Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad.Chen P, Tsuge H, Almassy RJ, Gribskov CL, Katoh S, Vanderpool DL, Margosiak SA, Pinko C, Matthews DA, Kan CC.Chen P, et al.Cell. 1996 Sep 6;86(5):835-43. doi: 10.1016/s0092-8674(00)80157-9.Cell. 1996.PMID:8797829
- Dissecting the catalytic triad of a serine protease.Carter P, Wells JA.Carter P, et al.Nature. 1988 Apr 7;332(6164):564-8. doi: 10.1038/332564a0.Nature. 1988.PMID:3282170
Cited by
- Small Peptides in the Detection of Mycotoxins and Their Potential Applications in Mycotoxin Removal.Zhao Z, Zhang Z, Zhang H, Liang Z.Zhao Z, et al.Toxins (Basel). 2022 Nov 16;14(11):795. doi: 10.3390/toxins14110795.Toxins (Basel). 2022.PMID:36422969Free PMC article.Review.
- Molecular intercommunication between the complement and coagulation systems.Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, Brückner UB, Nilsson B, Gebhard F, Lambris JD, Huber-Lang M.Amara U, et al.J Immunol. 2010 Nov 1;185(9):5628-36. doi: 10.4049/jimmunol.0903678. Epub 2010 Sep 24.J Immunol. 2010.PMID:20870944Free PMC article.
- Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.You BJ, Hour MJ, Chen LY, Luo SC, Hsu PH, Lee HZ.You BJ, et al.Sci Rep. 2019 Mar 1;9(1):3306. doi: 10.1038/s41598-019-39778-y.Sci Rep. 2019.PMID:30824767Free PMC article.
- Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA.Chua EG, Al-Hasani K, Scanlon M, Adler B, Sakellaris H.Chua EG, et al.Curr Microbiol. 2015 Nov;71(5):613-7. doi: 10.1007/s00284-015-0893-8. Epub 2015 Aug 22.Curr Microbiol. 2015.PMID:26297175
- zmsbt1 and zmsbt2, two new subtilisin-like serine proteases genes expressed in early maize kernel development.López M, Gómez E, Faye C, Gerentes D, Paul W, Royo J, Hueros G, Muñiz LM.López M, et al.Planta. 2017 Feb;245(2):409-424. doi: 10.1007/s00425-016-2615-2. Epub 2016 Nov 9.Planta. 2017.PMID:27830397
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources