Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
- PMID:15735111
- DOI: 10.1093/jn/135.3.660S
Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
Abstract
A randomized, double-blind, placebo-controlled trial was performed to assess the efficacy of different micronutrient supplementation regimes for improving micronutrient status, preventing anemia, and growth faltering of Vietnamese infants. A population-based sample of 306 infants aged 6-12 mo, split in 4 treatment groups, received daily multiple micronutrient (DMM), daily placebo (P), weekly multiple micronutrient (WMM), or daily iron (DI) supplements for 6 mo, 7 d/wk, under supervision. Weight and length were measured monthly, and anemia and plasma levels of ferritin, zinc, riboflavin, retinol, tocopherol, and homocysteine were determined before and after the supplementation. Z-scores for length-for-age and weight-for-age worsened significantly in all groups, but the length-for-age Z-score decreased significantly less in the DMM group (-0.32 +/- 0.05) than in the P and WMM groups (-0.49 +/- 0.05 and -0.51 +/- 0.05, respectively, P = 0.001). Hemoglobin levels increased significantly more in the DMM group [mean (95%CI): 16.4 g/L (12.4-20.4)] than in the P group [8.6 g/L (5.0-12.2), P = 0.04), with intermediate nonsignificant increases in the WMM [15.0 g/L (11.5-18.5)] and the DI [12.9 g/L (8.4-17.3)] groups. Ferritin changes were significantly greater in DMM (12.1 microg/L) and DI (9.5 microg/L) than in P (-14.7 microg/L) and WMM groups (-9.7 microg/L). Of the other micronutrients, only tocopherol showed a significantly greater level in the DMM group compared with P. Anemia still affected a quarter and zinc deficiency affected a third of infants although there was no iron deficiency after 6 mo of supplementation with DMM, suggesting that multiple factors are causing anemia and that the dose of zinc is too small.
Similar articles
- Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, double-blind, placebo-controlled trial.Untoro J, Karyadi E, Wibowo L, Erhardt MW, Gross R.Untoro J, et al.J Nutr. 2005 Mar;135(3):639S-645S. doi: 10.1093/jn/135.3.639S.J Nutr. 2005.PMID:15735108Clinical Trial.
- Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants.Smuts CM, Dhansay MA, Faber M, van Stuijvenberg ME, Swanevelder S, Gross R, Benadé AJ.Smuts CM, et al.J Nutr. 2005 Mar;135(3):653S-659S. doi: 10.1093/jn/135.3.653S.J Nutr. 2005.PMID:15735110Clinical Trial.
- Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants.López de Romaña G, Cusirramos S, López de Romaña D, Gross R.López de Romaña G, et al.J Nutr. 2005 Mar;135(3):646S-652S. doi: 10.1093/jn/135.3.646S.J Nutr. 2005.PMID:15735109Clinical Trial.
- Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age (Review).De-Regil LM, Suchdev PS, Vist GE, Walleser S, Peña-Rosas JP.De-Regil LM, et al.Evid Based Child Health. 2013 Jan;8(1):112-201. doi: 10.1002/ebch.1895.Evid Based Child Health. 2013.PMID:23878126Review.
- Micronutrient supplementation in adults with HIV infection.Visser ME, Durao S, Sinclair D, Irlam JH, Siegfried N.Visser ME, et al.Cochrane Database Syst Rev. 2017 May 18;5(5):CD003650. doi: 10.1002/14651858.CD003650.pub4.Cochrane Database Syst Rev. 2017.PMID:28518221Free PMC article.Review.
Cited by
- Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial.M C Lobo L, M Schincaglia R, G Peixoto MDR, C M Hadler MC.M C Lobo L, et al.Nutrients. 2019 Nov 11;11(11):2730. doi: 10.3390/nu11112730.Nutrients. 2019.PMID:31717948Free PMC article.Clinical Trial.
- Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial.Sazawal S, Dhingra U, Dhingra P, Hiremath G, Sarkar A, Dutta A, Menon VP, Black RE.Sazawal S, et al.PLoS One. 2010 Aug 13;5(8):e12167. doi: 10.1371/journal.pone.0012167.PLoS One. 2010.PMID:20730057Free PMC article.Clinical Trial.
- Effect of zinc and multivitamin supplementation on the growth of Tanzanian children aged 6-84 wk: a randomized, placebo-controlled, double-blind trial.Locks LM, Manji KP, McDonald CM, Kupka R, Kisenge R, Aboud S, Wang M, Fawzi WW, Duggan CP.Locks LM, et al.Am J Clin Nutr. 2016 Mar;103(3):910-8. doi: 10.3945/ajcn.115.120055. Epub 2016 Jan 27.Am J Clin Nutr. 2016.PMID:26817503Free PMC article.Clinical Trial.
- Intermittent iron supplementation for improving nutrition and development in children under 12 years of age.De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T.De-Regil LM, et al.Cochrane Database Syst Rev. 2011 Dec 7;2011(12):CD009085. doi: 10.1002/14651858.CD009085.pub2.Cochrane Database Syst Rev. 2011.PMID:22161444Free PMC article.Review.
- Micronutrient deficits are still public health issues among women and young children in Vietnam.Laillou A, Pham TV, Tran NT, Le HT, Wieringa F, Rohner F, Fortin S, Le MB, Tran do T, Moench-Pfanner R, Berger J.Laillou A, et al.PLoS One. 2012;7(4):e34906. doi: 10.1371/journal.pone.0034906. Epub 2012 Apr 17.PLoS One. 2012.PMID:22529954Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical