Review
doi: 10.1080/08977190400000833.Human interferons alpha, beta and omega
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- PMID:15621727
- DOI: 10.1080/08977190400000833
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Review
Human interferons alpha, beta and omega
Joseph Bekisz et al. Growth Factors.2004 Dec.
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Abstract
Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.
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