Review
doi: 10.1016/j.bbamcr.2004.09.022.Productive RUPture: activation of transcription factors by proteasomal processing
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- DOI: 10.1016/j.bbamcr.2004.09.022
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Review
Productive RUPture: activation of transcription factors by proteasomal processing
Michael Rape et al. Biochim Biophys Acta..
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Abstract
Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.
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