Effects of imidazenil, a new benzodiazepine receptor partial agonist, in the treatment of convulsions in organophosphate intoxications
- PMID:15545002
- DOI: 10.1007/BF03033323
Effects of imidazenil, a new benzodiazepine receptor partial agonist, in the treatment of convulsions in organophosphate intoxications
Abstract
Anticonvulsant and antilethal effects of imidazenil, a new imidazobenzodiazepine derivative, in fluostigmine (DFP; diisopropyl phosphorofluoridate) intoxications were studied and compared with the effects of diazepam on mice and rats. Special attention was payed to the myorelaxant effects of both drugs. It was stated that imidazenil (i) significantly decreased convulsion intensity in mice, (ii) quickly inhibited seizure patterns in bioelectrical activity in the rat's brain, (iii) significantly increased antilethal effectiveness of the standard therapy in mice intoxicated with DFP. These effects are comparable to those of diazepam. However, effects of imidazenil in the rota-rod test of the mouse were noted in doses 5-10 times higher than therapeutic ones, when effects of diazepam on motor co-ordination were seen in therapeutic dosage.
Similar articles
- Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage.Kadriu B, Gocel J, Larson J, Guidotti A, Davis JM, Nambiar MP, Auta J.Kadriu B, et al.Neuropharmacology. 2011 Dec;61(8):1463-9. doi: 10.1016/j.neuropharm.2011.08.043. Epub 2011 Sep 2.Neuropharmacology. 2011.PMID:21903116
- Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.Kadriu B, Guidotti A, Costa E, Auta J.Kadriu B, et al.Toxicology. 2009 Feb 27;256(3):164-74. doi: 10.1016/j.tox.2008.11.021. Epub 2008 Dec 7.Toxicology. 2009.PMID:19111886
- Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity.Auta J, Costa E, Davis J, Guidotti A.Auta J, et al.Neuropharmacology. 2004 Mar;46(3):397-403. doi: 10.1016/j.neuropharm.2003.09.010.Neuropharmacology. 2004.PMID:14975695
- Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.Appleton R, Martland T, Phillips B.Appleton R, et al.Cochrane Database Syst Rev. 2002;(4):CD001905. doi: 10.1002/14651858.CD001905.Cochrane Database Syst Rev. 2002.Update in:Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001905. doi: 10.1002/14651858.CD001905.pub2.PMID:12519562Updated.Review.
- From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.Costa E.Costa E.Annu Rev Pharmacol Toxicol. 1998;38:321-50. doi: 10.1146/annurev.pharmtox.38.1.321.Annu Rev Pharmacol Toxicol. 1998.PMID:9597158Review.
Cited by
- The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A.Pibiri F, et al.Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14169-74. doi: 10.1073/pnas.0807172105. Epub 2008 Sep 10.Proc Natl Acad Sci U S A. 2008.PMID:18784370Free PMC article.