Neural networks underlying endogenous and exogenous visual-spatial orienting
- PMID:15488402
- DOI: 10.1016/j.neuroimage.2004.06.027
Neural networks underlying endogenous and exogenous visual-spatial orienting
Abstract
The orienting of visual-spatial attention is fundamental to most organisms and is controlled through external (exogenous) or internal (endogenous) processes. Exogenous orienting is considered to be reflexive and automatic, whereas endogenous orienting refers to the purposeful allocation of attentional resources to a predetermined location in space. Although behavioral, electrophysiological and lesion research in both primates and humans suggests that separate neural systems control these different modes of orienting, previous human neuroimaging studies have largely reported common neuronal substrates. Therefore, event-related FMRI (ER-FMRI) was used to independently examine different components of the orienting response including endogenous facilitation, exogenous facilitation and inhibition of return (IOR). In contrast to previous studies, endogenous versus exogenous facilitation resulted in widespread cortical activation including bilateral temporoparietal junction, bilateral superior temporal gyrus, right middle temporal gyrus, right frontal eye field and left intraparietal sulcus. Conversely, IOR compared to endogenous facilitation resulted in only a single focus of activation in the left superior temporal gyrus. These findings suggest that endogenous orienting activates a large cortical network to achieve internally generated shifts of attentional resources versus the automatic orienting that occurs with exogenous cues. However, similar networks may mediate endogenous orienting and IOR. The activation of the temporoparietal junction suggests that it is involved in more effortful processes, such as endogenous orienting, as well as in attentional reorienting and locating targets. Current results are discussed in terms of the functional development of the visual-spatial attentional system.
Similar articles
- Neural correlates of the spatial and expectancy components of endogenous and stimulus-driven orienting of attention in the Posner task.Doricchi F, Macci E, Silvetti M, Macaluso E.Doricchi F, et al.Cereb Cortex. 2010 Jul;20(7):1574-85. doi: 10.1093/cercor/bhp215. Epub 2009 Oct 21.Cereb Cortex. 2010.PMID:19846472
- An event-related fMRI Study of exogenous facilitation and inhibition of return in the auditory modality.Mayer AR, Harrington DL, Stephen J, Adair JC, Lee RR.Mayer AR, et al.J Cogn Neurosci. 2007 Mar;19(3):455-67. doi: 10.1162/jocn.2007.19.3.455.J Cogn Neurosci. 2007.PMID:17335394Clinical Trial.
- Control networks and hemispheric asymmetries in parietal cortex during attentional orienting in different spatial reference frames.Wilson KD, Woldorff MG, Mangun GR.Wilson KD, et al.Neuroimage. 2005 Apr 15;25(3):668-83. doi: 10.1016/j.neuroimage.2004.07.075.Neuroimage. 2005.PMID:15808968
- Dynamics of emotional effects on spatial attention in the human visual cortex.Pourtois G, Vuilleumier P.Pourtois G, et al.Prog Brain Res. 2006;156:67-91. doi: 10.1016/S0079-6123(06)56004-2.Prog Brain Res. 2006.PMID:17015075Review.
- Two cognitive and neural systems for endogenous and exogenous spatial attention.Chica AB, Bartolomeo P, Lupiáñez J.Chica AB, et al.Behav Brain Res. 2013 Jan 15;237:107-23. doi: 10.1016/j.bbr.2012.09.027. Epub 2012 Sep 21.Behav Brain Res. 2013.PMID:23000534Review.
Cited by
- Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study.De Witt Hamer PC, Moritz-Gasser S, Gatignol P, Duffau H.De Witt Hamer PC, et al.Hum Brain Mapp. 2011 Jun;32(6):962-73. doi: 10.1002/hbm.21082. Epub 2010 Jun 24.Hum Brain Mapp. 2011.PMID:20578169Free PMC article.
- Voluntary and involuntary attention affect face discrimination differently.Esterman M, Prinzmetal W, DeGutis J, Landau A, Hazeltine E, Verstynen T, Robertson L.Esterman M, et al.Neuropsychologia. 2008 Mar 7;46(4):1032-40. doi: 10.1016/j.neuropsychologia.2007.11.014. Epub 2007 Nov 23.Neuropsychologia. 2008.PMID:18166203Free PMC article.
- Unilateral Stimulation of Subthalamic Nucleus Does Not Affect Inhibitory Control.Mancini C, Modugno N, Santilli M, Pavone L, Grillea G, Morace R, Mirabella G.Mancini C, et al.Front Neurol. 2019 Jan 7;9:1149. doi: 10.3389/fneur.2018.01149. eCollection 2018.Front Neurol. 2019.PMID:30666229Free PMC article.
- FMRI correlates of visuo-spatial reorienting investigated with an attention shifting double-cue paradigm.Natale E, Marzi CA, Macaluso E.Natale E, et al.Hum Brain Mapp. 2009 Aug;30(8):2367-81. doi: 10.1002/hbm.20675.Hum Brain Mapp. 2009.PMID:19034897Free PMC article.
- Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis.Daumann J, Heekeren K, Neukirch A, Thiel CM, Möller-Hartmann W, Gouzoulis-Mayfrank E.Daumann J, et al.Psychopharmacology (Berl). 2008 Nov;200(4):573-83. doi: 10.1007/s00213-008-1237-1. Epub 2008 Jul 24.Psychopharmacology (Berl). 2008.PMID:18649072Clinical Trial.
Publication types
MeSH terms
Related information
Grants and funding
LinkOut - more resources
Full Text Sources