Periodic gene expression program of the fission yeast cell cycle
- PMID:15195092
- DOI: 10.1038/ng1377
Periodic gene expression program of the fission yeast cell cycle
Abstract
Cell-cycle control of transcription seems to be universal, but little is known about its global conservation and biological significance. We report on the genome-wide transcriptional program of the Schizosaccharomyces pombe cell cycle, identifying 407 periodically expressed genes of which 136 show high-amplitude changes. These genes cluster in four major waves of expression. The forkhead protein Sep1p regulates mitotic genes in the first cluster, including Ace2p, which activates transcription in the second cluster during the M-G1 transition and cytokinesis. Other genes in the second cluster, which are required for G1-S progression, are regulated by the MBF complex independently of Sep1p and Ace2p. The third cluster coincides with S phase and a fourth cluster contains genes weakly regulated during G2 phase. Despite conserved cell-cycle transcription factors, differences in regulatory circuits between fission and budding yeasts are evident, revealing evolutionary plasticity of transcriptional control. Periodic transcription of most genes is not conserved between the two yeasts, except for a core set of approximately 40 genes that seem to be universally regulated during the eukaryotic cell cycle and may have key roles in cell-cycle progression.
Comment in
- STARTing to recycle.Sherlock G.Sherlock G.Nat Genet. 2004 Aug;36(8):795-6. doi: 10.1038/ng0804-795.Nat Genet. 2004.PMID:15284848No abstract available.
Similar articles
- A transcriptional pathway for cell separation in fission yeast.Bähler J.Bähler J.Cell Cycle. 2005 Jan;4(1):39-41. doi: 10.4161/cc.4.1.1336. Epub 2005 Jan 29.Cell Cycle. 2005.PMID:15611619Review.
- Cell-cycle control of gene expression in budding and fission yeast.Bähler J.Bähler J.Annu Rev Genet. 2005;39:69-94. doi: 10.1146/annurev.genet.39.110304.095808.Annu Rev Genet. 2005.PMID:16285853Review.
- The cell cycle-regulated genes of Schizosaccharomyces pombe.Oliva A, Rosebrock A, Ferrezuelo F, Pyne S, Chen H, Skiena S, Futcher B, Leatherwood J.Oliva A, et al.PLoS Biol. 2005 Jul;3(7):e225. doi: 10.1371/journal.pbio.0030225. Epub 2005 Jun 28.PLoS Biol. 2005.PMID:15966770Free PMC article.
- Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast.Buck V, Ng SS, Ruiz-Garcia AB, Papadopoulou K, Bhatti S, Samuel JM, Anderson M, Millar JB, McInerny CJ.Buck V, et al.J Cell Sci. 2004 Nov 1;117(Pt 23):5623-32. doi: 10.1242/jcs.01473.J Cell Sci. 2004.PMID:15509866
- Identification of cell cycle-regulated genes in fission yeast.Peng X, Karuturi RK, Miller LD, Lin K, Jia Y, Kondu P, Wang L, Wong LS, Liu ET, Balasubramanian MK, Liu J.Peng X, et al.Mol Biol Cell. 2005 Mar;16(3):1026-42. doi: 10.1091/mbc.e04-04-0299. Epub 2004 Dec 22.Mol Biol Cell. 2005.PMID:15616197Free PMC article.
Cited by
- CK1-mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment.Aquino Perez C, Burocziova M, Jenikova G, Macurek L.Aquino Perez C, et al.EMBO Rep. 2021 Jul 5;22(7):e51847. doi: 10.15252/embr.202051847. Epub 2021 May 26.EMBO Rep. 2021.PMID:34080749Free PMC article.
- RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.Nakazawa N, Sajiki K, Xu X, Villar-Briones A, Arakawa O, Yanagida M.Nakazawa N, et al.Genes Cells. 2015 Jun;20(6):481-99. doi: 10.1111/gtc.12239. Epub 2015 Apr 6.Genes Cells. 2015.PMID:25847133Free PMC article.
- Matching experiments across species using expression values and textual information.Wise A, Oltvai ZN, Bar-Joseph Z.Wise A, et al.Bioinformatics. 2012 Jun 15;28(12):i258-64. doi: 10.1093/bioinformatics/bts205.Bioinformatics. 2012.PMID:22689770Free PMC article.
- Frequency-based time-series gene expression recomposition using PRIISM.Rosa BA, Jiao Y, Oh S, Montgomery BL, Qin W, Chen J.Rosa BA, et al.BMC Syst Biol. 2012 Jun 15;6:69. doi: 10.1186/1752-0509-6-69.BMC Syst Biol. 2012.PMID:22703599Free PMC article.
- Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes.Taylor JM, Street TL, Hao L, Copley R, Taylor MS, Hayden PJ, Stolper G, Mott R, Hein J, Moffatt MF, Cookson WO.Taylor JM, et al.PLoS One. 2009 Oct 30;4(10):e7651. doi: 10.1371/journal.pone.0007651.PLoS One. 2009.PMID:19888454Free PMC article.
Publication types
MeSH terms
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases