doi: 10.1021/jm0341204.
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp
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- PMID:14613313
- DOI: 10.1021/jm0341204
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A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp
María J Vázquez et al. J Med Chem..
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Abstract
In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This compound has a pK(i) of 10.2 versus the 5-hydroxytryptamine(1A) receptor subtype. The structure was elucidated by extensive NMR spectroscopy and mass spectrometry.
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