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.1992 Mar 25;267(9):5735-8.

Characterization of the human 5-hydroxytryptamine1B receptor

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  • PMID:1348246
Free article

Characterization of the human 5-hydroxytryptamine1B receptor

H Jin et al. J Biol Chem..
Free article

Abstract

We report the cloning of a human gene encoding the 5-hydroxytryptamine1B receptor. The receptor has the characteristics of a G-protein-linked receptor and is most homologous to the human 5-HT1D receptor. This human 5-HT receptor gene, most abundantly expressed in striatum, is localized on chromosome 6, at 6q13, and the gene encoding the 5-HT1D receptor is localized on chromosome 1. Radioligand studies indicate that the affinity of [3H]5-HT is 16 +/- 2 nM. Drug competition studies indicate that the receptor displays high affinity (i.e. less than 40 nM) for 5-HT, 5-carboxyamidotryptamine, methiothepin, and metergoline.

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