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Case Reports
.2003 Jun 10;60(11):1841-3.
doi: 10.1212/01.wnl.0000061482.24750.7c.

Non-24-hour sleep-wake syndrome following a car accident

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Case Reports

Non-24-hour sleep-wake syndrome following a car accident

D B Boivin et al. Neurology..

Abstract

The authors report the case of a 39-year-old sighted woman who displayed non-24-hour sleep-wake cycles following a car accident. The phase relationship between endogenous circadian markers such as plasma melatonin and 6-sulfatoxymelatonin rhythms and self-selected sleep times was abnormal. A laboratory investigation indicated that she was sensitive to bright light as a circadian synchronizer. MRI and brain CT scans were normal, but microscopic brain damage in the vicinity of the suprachiasmatic nucleus or its output pathways is plausible.

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