doi: 10.1016/S0140-6736(03)13491-5.
Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene
Affiliations
- PMID:12788577
- DOI: 10.1016/S0140-6736(03)13491-5
Item in Clipboard
Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene
Manda Rossouw et al. Lancet..
Display options
Format
Display options
Format
Abstract
Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis.
Similar articles
- IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis.Vallinoto AC, Graça ES, Araújo MS, Azevedo VN, Cayres-Vallinoto I, Machado LF, Ishak MO, Ishak R.Vallinoto AC, et al.Hum Immunol. 2010 Jul;71(7):692-6. doi: 10.1016/j.humimm.2010.03.008. Epub 2010 Apr 27.Hum Immunol. 2010.PMID:20353805
- Interferon-gamma gene (T874A and G2109A) polymorphisms are associated with microscopy-positive tuberculosis.Etokebe GE, Bulat-Kardum L, Johansen MS, Knezevic J, Balen S, Matakovic-Mileusnic N, Matanic D, Flego V, Pavelic J, Beg-Zec Z, Dembic Z.Etokebe GE, et al.Scand J Immunol. 2006 Feb;63(2):136-41. doi: 10.1111/j.1365-3083.2005.01716.x.Scand J Immunol. 2006.PMID:16476013
- Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis.Bulat-Kardum L, Etokebe GE, Knezevic J, Balen S, Matakovic-Mileusnic N, Zaputovic L, Pavelic J, Beg-Zec Z, Dembic Z.Bulat-Kardum L, et al.Scand J Immunol. 2006 Feb;63(2):142-50. doi: 10.1111/j.1365-3083.2005.01694.x.Scand J Immunol. 2006.PMID:16476014
- Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis.de Albuquerque AC, Rocha LQ, de Morais Batista AH, Teixeira AB, Dos Santos DB, Nogueira NA.de Albuquerque AC, et al.Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):2887-95. doi: 10.1007/s10096-012-1660-4. Epub 2012 Jun 9.Eur J Clin Microbiol Infect Dis. 2012.PMID:22684265Review.
- Genetic susceptibility to tuberculosis.Newport M, Levin M.Newport M, et al.J Infect. 1999 Sep;39(2):117-21. doi: 10.1016/s0163-4453(99)90002-6.J Infect. 1999.PMID:10609528Review.No abstract available.
Cited by
- Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape.de Wit E, Delport W, Rugamika CE, Meintjes A, Möller M, van Helden PD, Seoighe C, Hoal EG.de Wit E, et al.Hum Genet. 2010 Aug;128(2):145-53. doi: 10.1007/s00439-010-0836-1. Epub 2010 May 20.Hum Genet. 2010.PMID:20490549
- Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV.Cooke GS, et al.Am J Respir Crit Care Med. 2008 Jul 15;178(2):203-7. doi: 10.1164/rccm.200710-1554OC. Epub 2008 Apr 17.Am J Respir Crit Care Med. 2008.PMID:18420963Free PMC article.
- Network Analysis of Human Genes Influencing Susceptibility to Mycobacterial Infections.Lipner EM, Garcia BJ, Strong M.Lipner EM, et al.PLoS One. 2016 Jan 11;11(1):e0146585. doi: 10.1371/journal.pone.0146585. eCollection 2016.PLoS One. 2016.PMID:26751573Free PMC article.
- Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.Hassuna NA, El Feky M, Hussein AARM, Mahmoud MA, Idriss NK, Abdelwahab SF, Ibrahim MA.Hassuna NA, et al.PLoS One. 2021 Jan 7;16(1):e0244949. doi: 10.1371/journal.pone.0244949. eCollection 2021.PLoS One. 2021.PMID:33412574Free PMC article.
- Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions WithinMycobacterium tuberculosis Granulomas.Millar JA, Butler JR, Evans S, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE.Millar JA, et al.Front Immunol. 2021 Jan 20;11:613638. doi: 10.3389/fimmu.2020.613638. eCollection 2020.Front Immunol. 2021.PMID:33552077Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical