doi: 10.1016/s1570-9639(03)00059-1.
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved
Affiliations
- PMID:12686141
- DOI: 10.1016/s1570-9639(03)00059-1
Item in Clipboard
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved
Monia Giampuzzi et al. Biochim Biophys Acta..
Display options
Format
Display options
Format
Abstract
Lysyl oxidase (LOX) is the enzyme that cross-links extracellular collagen and tropoelastin and is involved in tumor suppressor activity. Based on the existent homologies between lysine-rich regions of tropoelastin and the "lysine-rich" histone H1, we tested the possibility that H1 could be a new nuclear target. Our study shows that LOX could actually interact specifically not only with histone H1, but also with histone H2. Mechanisms and significance of these interactions are discussed in detail.
Similar articles
- Lysyl oxidase regulates MMTV promoter: indirect evidence of histone H1 involvement.Oleggini R, Di Donato A.Oleggini R, et al.Biochem Cell Biol. 2011 Dec;89(6):522-32. doi: 10.1139/o11-049. Epub 2011 Oct 14.Biochem Cell Biol. 2011.PMID:21999391
- The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P.Thomassin L, et al.J Biol Chem. 2005 Dec 30;280(52):42848-55. doi: 10.1074/jbc.M506832200. Epub 2005 Oct 26.J Biol Chem. 2005.PMID:16251195
- Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation.Fogelgren B, Polgár N, Szauter KM, Ujfaludi Z, Laczkó R, Fong KS, Csiszar K.Fogelgren B, et al.J Biol Chem. 2005 Jul 1;280(26):24690-7. doi: 10.1074/jbc.M412979200. Epub 2005 Apr 19.J Biol Chem. 2005.PMID:15843371
- Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.Kagan HM, Li W.Kagan HM, et al.J Cell Biochem. 2003 Mar 1;88(4):660-72. doi: 10.1002/jcb.10413.J Cell Biochem. 2003.PMID:12577300Review.
- Structural and functional diversity of lysyl oxidase and the LOX-like proteins.Molnar J, Fong KS, He QP, Hayashi K, Kim Y, Fong SF, Fogelgren B, Szauter KM, Mink M, Csiszar K.Molnar J, et al.Biochim Biophys Acta. 2003 Apr 11;1647(1-2):220-4. doi: 10.1016/s1570-9639(03)00053-0.Biochim Biophys Acta. 2003.PMID:12686136Review.
Cited by
- Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein.Saleem A, Rajput S.Saleem A, et al.J Genet Eng Biotechnol. 2020 Jun 16;18(1):20. doi: 10.1186/s43141-020-00034-w.J Genet Eng Biotechnol. 2020.PMID:32542505Free PMC article.
- Hypoxia, inflammation, and the tumor microenvironment in metastatic disease.Finger EC, Giaccia AJ.Finger EC, et al.Cancer Metastasis Rev. 2010 Jun;29(2):285-93. doi: 10.1007/s10555-010-9224-5.Cancer Metastasis Rev. 2010.PMID:20393783Free PMC article.Review.
- Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges.Martínez-González J, Varona S, Cañes L, Galán M, Briones AM, Cachofeiro V, Rodríguez C.Martínez-González J, et al.Biomolecules. 2019 Oct 14;9(10):610. doi: 10.3390/biom9100610.Biomolecules. 2019.PMID:31615160Free PMC article.Review.
- Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma.Liep J, Kilic E, Meyer HA, Busch J, Jung K, Rabien A.Liep J, et al.PLoS One. 2016 Jun 23;11(6):e0157801. doi: 10.1371/journal.pone.0157801. eCollection 2016.PLoS One. 2016.PMID:27336447Free PMC article.
- Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis.Zaffryar-Eilot S, Hasson P.Zaffryar-Eilot S, et al.Int J Mol Sci. 2022 Sep 27;23(19):11378. doi: 10.3390/ijms231911378.Int J Mol Sci. 2022.PMID:36232685Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources