Expression of NKX3.1 in normal and malignant tissues
- PMID:12661036
- DOI: 10.1002/pros.10210
Expression of NKX3.1 in normal and malignant tissues
Abstract
Background: NKX3.1, a member of the NK-class of homeodomain proteins, is expressed primarily in the adult prostate and has growth suppression and differentiating effects in prostate epithelial cells.
Methods: We performed immunohistochemical analysis for NKX3.1 and PSA expression in 4,061 samples included in a tissue microarray of a broad spectrum of human cancers and normal tissues.
Results: NKX3.1 expression was seen in prostate epithelial cells, prostate cancer, normal testis, 9% of primary and 5% of metastatic infiltrating ductal breast carcinoma, and 27% of primary and 26% of metastatic infiltrating lobular breast carcinoma. In a cohort of 474 primary breast cancers with median follow-up over 62.5 month survival, we found no effect of NKX3.1 expression on prognosis. NKX3.1 expression was more restricted than the spectrum of prostate specific antigen expression.
Conclusions: Expression of NKX3.1 is highly restricted and is found primarily in benign and malignant prostatic epithelial cells and also in normal testis and lobular carcinoma of the breast.
Copyright 2003 Wiley-Liss, Inc.
Similar articles
- Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.Bowen C, Bubendorf L, Voeller HJ, Slack R, Willi N, Sauter G, Gasser TC, Koivisto P, Lack EE, Kononen J, Kallioniemi OP, Gelmann EP.Bowen C, et al.Cancer Res. 2000 Nov 1;60(21):6111-5.Cancer Res. 2000.PMID:11085535
- Analysis of NKX3.1 expression in prostate cancer tissues and correlation with clinicopathologic features.Aslan G, Irer B, Tuna B, Yorukoglu K, Saatcioglu F, Celebi I.Aslan G, et al.Pathol Res Pract. 2006;202(2):93-8. doi: 10.1016/j.prp.2005.11.007. Epub 2006 Jan 18.Pathol Res Pract. 2006.PMID:16413692
- [The specific expression profile of homeobox gene NKX3.1 mRNA and protein in prostate tissues and its relationship with primary prostate cancer].Yang GS, Wang YM, Chen ZD.Yang GS, et al.Zhonghua Nan Ke Xue. 2006 Feb;12(2):137-40, 144.Zhonghua Nan Ke Xue. 2006.PMID:16519150Chinese.
- Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.Abdulkadir SA.Abdulkadir SA.Ann N Y Acad Sci. 2005 Nov;1059:33-40. doi: 10.1196/annals.1339.018.Ann N Y Acad Sci. 2005.PMID:16382041Review.
- Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants.Padmanabhan A, Rao V, De Marzo AM, Bieberich CJ.Padmanabhan A, et al.Prostate. 2016 May;76(6):523-33. doi: 10.1002/pros.23144. Epub 2016 Feb 4.Prostate. 2016.PMID:26841725Review.
Cited by
- A comparison of prostatic development in xenografts of human fetal prostate and human female fetal proximal urethra grown in dihydrotestosterone-treated hosts.Cunha GR, Cao M, Franco O, Baskin LS.Cunha GR, et al.Differentiation. 2020 Sep-Oct;115:37-52. doi: 10.1016/j.diff.2020.06.001. Epub 2020 Jul 14.Differentiation. 2020.PMID:32861072Free PMC article.
- TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells.Eide T, Ramberg H, Glackin C, Tindall D, Taskén KA.Eide T, et al.Cancer Cell Int. 2013 Jan 31;13(1):4. doi: 10.1186/1475-2867-13-4.Cancer Cell Int. 2013.PMID:23368843Free PMC article.
- NKX3-1 Is a Useful Immunohistochemical Marker of EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma.Yoshida KI, Machado I, Motoi T, Parafioriti A, Lacambra M, Ichikawa H, Kawai A, Antonescu CR, Yoshida A.Yoshida KI, et al.Am J Surg Pathol. 2020 Jun;44(6):719-728. doi: 10.1097/PAS.0000000000001441.Am J Surg Pathol. 2020.PMID:31972596Free PMC article.
- The diagnostic challenges of differentiating metastatic extramammary Paget disease and prostatic adenocarcinoma: A case report and review of the literature.Palmateer G, Nicaise EH, Gandhi J, Goodstein T, Sheng M, Ogan K, Kucuk O, Yushak M, Sanda MG, Delman KA, Master V.Palmateer G, et al.Urol Case Rep. 2024 Oct 24;57:102875. doi: 10.1016/j.eucr.2024.102875. eCollection 2024 Nov.Urol Case Rep. 2024.PMID:39553440Free PMC article.
- Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer.Heylen E, Verstraete P, Van Aerschot L, Geeraerts SL, Venken T, Timcheva K, Nittner D, Verbeeck J, Royaert J, Gijbels M, Uyttebroeck A, Segers H, Lambrechts D, Cools J, De Keersmaecker K, Kampen KR.Heylen E, et al.Br J Cancer. 2023 May;128(10):1862-1878. doi: 10.1038/s41416-023-02216-y. Epub 2023 Mar 17.Br J Cancer. 2023.PMID:36932191Free PMC article.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous