doi: 10.1126/science.1265483.
Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras
- PMID:1265483
- DOI: 10.1126/science.1265483
Item in Clipboard
Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras
R J Mullen et al. Science..
Display options
Format
Display options
Format
Abstract
Chimeric rats were produced by the aggregation of embryos of the pinkeyed, retinal dystrophic RCS strain with those of pigmented, normal rats. In the mosaic eyes, patches of neural retina with abnormal and degenerated photoreceptors were present only opposite patches of nonpigmented, mutant pigment epithelium. This indicates that the retinal dystrophy gene acts in the pigment epithelial cell rather than in the photoreceptor cell.
Similar articles
- The interphotoreceptor matrix in rats with inherited retinal dystrophy.LaVail MM, Pinto LH, Yasumura D.LaVail MM, et al.Invest Ophthalmol Vis Sci. 1981 Nov;21(5):658-68.Invest Ophthalmol Vis Sci. 1981.PMID:6170601
- Rat model for hereditary retinal degeneration.Lai YL, Jonas AM.Lai YL, et al.Adv Exp Med Biol. 1977;77:115-36. doi: 10.1007/978-1-4899-5010-9_11.Adv Exp Med Biol. 1977.PMID:848387
- Preservation of visual responsiveness in the superior colliculus of RCS rats after retinal pigment epithelium cell transplantation.Sauvé Y, Girman SV, Wang S, Keegan DJ, Lund RD.Sauvé Y, et al.Neuroscience. 2002;114(2):389-401. doi: 10.1016/s0306-4522(02)00271-3.Neuroscience. 2002.PMID:12204208
- Histopathology of the human retina in retinitis pigmentosa.Milam AH, Li ZY, Fariss RN.Milam AH, et al.Prog Retin Eye Res. 1998 Apr;17(2):175-205. doi: 10.1016/s1350-9462(97)00012-8.Prog Retin Eye Res. 1998.PMID:9695792Review.
- Transplantation of retinal pigment epithelial, photoreceptor and other cells as treatment for retinal degeneration.Litchfield TM, Whiteley SJ, Lund RD.Litchfield TM, et al.Exp Eye Res. 1997 May;64(5):655-66. doi: 10.1006/exer.1996.0253.Exp Eye Res. 1997.PMID:9245894Review.No abstract available.
Cited by
- In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function.Choi SS, Doble N, Hardy JL, Jones SM, Keltner JL, Olivier SS, Werner JS.Choi SS, et al.Invest Ophthalmol Vis Sci. 2006 May;47(5):2080-92. doi: 10.1167/iovs.05-0997.Invest Ophthalmol Vis Sci. 2006.PMID:16639019Free PMC article.
- Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions.Nandrot EF, Chang Y, Finnemann SC.Nandrot EF, et al.Adv Exp Med Biol. 2008;613:369-75. doi: 10.1007/978-0-387-74904-4_43.Adv Exp Med Biol. 2008.PMID:18188966Free PMC article.Review.No abstract available.
- Primary cilia and dendritic spines: different but similar signaling compartments.Nechipurenko IV, Doroquez DB, Sengupta P.Nechipurenko IV, et al.Mol Cells. 2013 Oct;36(4):288-303. doi: 10.1007/s10059-013-0246-z. Epub 2013 Sep 16.Mol Cells. 2013.PMID:24048681Free PMC article.Review.
- Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering.Ben M'Barek K, Monville C.Ben M'Barek K, et al.Stem Cells Int. 2019 Jan 23;2019:4568979. doi: 10.1155/2019/4568979. eCollection 2019.Stem Cells Int. 2019.PMID:30809263Free PMC article.Review.
- Retinitis pigmentosa: a quantitative study of the apical membrane of normal and dystrophic human retinal pigment epithelial cells in tissue culture in relation to phagocytosis.Boulton M, Marshall J, Mellerio J.Boulton M, et al.Graefes Arch Clin Exp Ophthalmol. 1984;221(5):214-29. doi: 10.1007/BF02134143.Graefes Arch Clin Exp Ophthalmol. 1984.PMID:6489769
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources