Review
doi: 10.1038/nrc723.Natural products in cancer chemotherapy: past, present and future
Affiliations
- PMID:12635177
- DOI: 10.1038/nrc723
Item in Clipboard
Review
Natural products in cancer chemotherapy: past, present and future
John Mann. Nat Rev Cancer.2002 Feb.
Display options
Format
Display options
Format
Abstract
Natural products have been the mainstay of cancer chemotherapy for the past 30 years. However, the quickening pace of (aberrant) gene identification, and the new technologies of combinatorial chemistry and high-throughput screening, should provide access to a wide range of new, totally synthetic drugs. Will these new approaches sound the death knell for therapies based on natural products? In reality, natural products are likely to provide many of the lead structures, and these will be used as templates for the construction of novel compounds with enhanced biological properties.
Similar articles
- Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery.Thirupathi A, Shanmugavadivelu CM, Natarajan S.Thirupathi A, et al.Curr Pharm Biotechnol. 2020;21(5):354-363. doi: 10.2174/1389201020666191128145015.Curr Pharm Biotechnol. 2020.PMID:31778106Review.
- Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.Zarins-Tutt JS, Abraham ER, Bailey CS, Goss RJ.Zarins-Tutt JS, et al.Prog Mol Subcell Biol. 2017;55:159-186. doi: 10.1007/978-3-319-51284-6_5.Prog Mol Subcell Biol. 2017.PMID:28238038Review.
- [Chemical study on bioactive natural products of novel structural types].Yu SS, Feng XZ.Yu SS, et al.Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Aug;26(4):347-50.Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004.PMID:15379253Chinese.
- Natural products as a screening resource.Harvey AL.Harvey AL.Curr Opin Chem Biol. 2007 Oct;11(5):480-4. doi: 10.1016/j.cbpa.2007.08.012. Epub 2007 Sep 19.Curr Opin Chem Biol. 2007.PMID:17884696Review.
- Plant natural products: back to the future or into extinction?McChesney JD, Venkataraman SK, Henri JT.McChesney JD, et al.Phytochemistry. 2007 Jul;68(14):2015-22. doi: 10.1016/j.phytochem.2007.04.032. Epub 2007 Jun 14.Phytochemistry. 2007.PMID:17574638
Cited by
- Therapeutic Potential of 5'-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma.Koubek EJ, Weissenrieder JS, Ortiz LE, Nwogu N, Pham AM, Weissenkampen JD, Reed JL, Neighbors JD, Hohl RJ, Kwun HJ.Koubek EJ, et al.Viruses. 2022 Aug 23;14(9):1848. doi: 10.3390/v14091848.Viruses. 2022.PMID:36146655Free PMC article.
- Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells.Kang JI, Hong JY, Choi JS, Lee SK.Kang JI, et al.Biomol Ther (Seoul). 2016 May 1;24(3):320-7. doi: 10.4062/biomolther.2015.145.Biomol Ther (Seoul). 2016.PMID:27098859Free PMC article.
- An Improved Method for P2X7R Antagonist Screening.Soares-Bezerra RJ, Ferreira NC, Alberto AV, Bonavita AG, Fidalgo-Neto AA, Calheiros AS, Frutuoso Vda S, Alves LA.Soares-Bezerra RJ, et al.PLoS One. 2015 May 19;10(5):e0123089. doi: 10.1371/journal.pone.0123089. eCollection 2015.PLoS One. 2015.PMID:25993132Free PMC article.
- Molecular interaction studies on ellagic acid for its anticancer potential targeting pyruvate dehydrogenase kinase 3.Dahiya R, Mohammad T, Gupta P, Haque A, Alajmi MF, Hussain A, Hassan MI.Dahiya R, et al.RSC Adv. 2019 Jul 29;9(40):23302-23315. doi: 10.1039/c9ra02864a. eCollection 2019 Jul 23.RSC Adv. 2019.PMID:35514501Free PMC article.
- Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.Jin HR, Du CH, Wang CZ, Yuan CS, Du W.Jin HR, et al.Phytother Res. 2019 Mar;33(3):610-617. doi: 10.1002/ptr.6249. Epub 2018 Dec 9.Phytother Res. 2019.PMID:30537241Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous